System and method for attaching soft tissue to an implant comprising a nanotextured surface

Patent metadata

Field	Value
Publication number	US-9498218-B2
Application number	US-201514603080-A
Country	US
Kind code	B2
Filing date	Jan 22, 2015
Priority date	Nov 12, 2004
Publication date	Nov 22, 2016
Grant date	Nov 22, 2016

Abstract

One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein the porous region exhibits a nano-textured surface, and a biocompatible polymer matrix coating the nano-textured surface. The polymer matrix coating comprises a naturally occurring extracellular matrix with biocompatible inorganic materials distributed within the matrix, or a biocompatible polymer and an osteo-inductive agent.

First claim

What is claimed is:

1. A kit for repairing a diarthrodial joint, the kit comprising:
a metal implant construct, the construct comprising
a metal implant comprising a porous region, wherein the porous region exhibits a nano-textured surface;
a calcified material layer coating the nano-textured surface;
an extender graft comprising a naturally occurring extracellular matrix, and a mesh member coupled to the naturally occurring extracellular matrix; and
a scaffold element, wherein the scaffold element comprises a biocompatible polymer matrix and a bioactive agent.

2. The kit of claim 1 wherein the scaffold element comprises a submucosal matrix.

3. The kit of claim 1 wherein the calcified material layer consists essentially of nano-scale hydroxyapatite particles.

4. A kit for repairing a diarthrodial joint, the kit comprising:
a metal implant construct, the construct comprising
a metal implant comprising a porous region, wherein the porous region exhibits a nano-textured surface; and
a calcified material layer coating the nano-textured surface; and
an extender graft comprising a naturally occurring extracellular matrix, and a mesh member coupled to the naturally occurring extracellular matrix, wherein the calcified material layer comprises a naturally occurring extracellular matrix and exogenously added biocompatible inorganic material.

5. The kit of claim 4 wherein the naturally occurring extracellular matrix includes intestinal submucosa that is prepared as a gel, with the biocompatible inorganic material dispersed within the naturally occurring extracellular matrix.

6. The kit of claim 5 wherein the biocompatible inorganic material comprises nano-scale hydroxyapatite crystals.

7. A method of attaching soft tissue to a metal implant, the method comprising the steps of
providing a metal implant construct, the construct comprising
a metal implant comprising a porous region, wherein the porous region exhibits a nano-textured surface; and
a biocompatible polymer matrix coating the nano-textured surface, wherein the biocompatible polymer matrix comprises a naturally occurring extracellular matrix and an exogenously added biocompatible inorganic material;
coupling at least a portion of a scaffold layer to the metal implant and in contact with the biocompatible polymer matrix, wherein the scaffold layer comprises a biocompatible polymer matrix and a growth factor;
attaching a proximal end of an extender portion to the scaffold layer, wherein the extender portion comprises a submucosal matrix, and a synthetic portion coupled to the submucosal matrix, the synthetic portion including a mesh member wherein the mesh member is coated with a naturally occurring extracellular matrix; and
attaching a distal end of the extender portion to a patient's soft tissue.

Assignees

• Purdue Research Foundation
• Depuy Synthes Products Inc

Inventors

• Venu Perla
• Malaviya Prasanna
• Webster Thomas J

Classifications

• A61F2310/0097

  Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L27/04

  Metals or alloys · CPC title

• A61F2002/30062

  (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive · CPC title

• A61K9/0024

  Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L) · CPC title