Robust calibration and self-correction for tissue oximetry probe

Patent metadata

Field	Value
Publication number	US-9498157-B2
Application number	US-201313887152-A
Country	US
Kind code	B2
Filing date	May 3, 2013
Priority date	May 3, 2012
Publication date	Nov 22, 2016
Grant date	Nov 22, 2016

Abstract

A method for calibrating detectors of a self-contained, tissue oximetry device includes emitting light from a light source into a tissue phantom, detecting in a plurality of detectors the light emitted from the light source, subsequent to reflection from the tissue phantom, and generating a set of detector responses by the plurality of detectors based on detecting the light emitted from the light source. The method further includes determining a set of differences between the set of detector responses and a reflectance curve for the tissue phantom, and generating a set of calibration functions based on the set of differences. Each calibration function in the set of calibration functions is associated with a unique, light source-detector pair. The method further includes storing the set of calibration function in a memory of the self-contained, tissue oximetry device.

First claim

The invention claimed is:

1. A method for calibrating detectors of a tissue oximetry device comprising:
transmitting source electrical signals to a first light source and a second light source;
transforming, by the first and second light sources, the electrical signals into light based on the source electrical signals, emitting light having at least two wavelengths into a first tissue phantom from a first source structure and a second source structure that are optically coupled respectively to the first and second light sources;
detecting the light by a plurality of detector structures, subsequent to reflection from the first tissue phantom, wherein the plurality of detector structures comprises a first detector structure, a second detector structure, a third detector structure, and a fourth detector structure,
the first and second source structures and the first, second, third, and fourth detector structures are arranged on a probe face of the tissue oximetry device,
a first distance is from the first detector structure to the first source structure,
a second distance is from the first detector structure to the second source structure,
the first distance is greater than the second distance,
a third distance is from the second detector structure to the first source structure,
a fourth distance is from the second detector structure to the second source structure,
the fourth distance is greater than the third distance,
a fifth distance is from the third detector structure to the first source structure,
a sixth distance is from the third detector structure to the second source structure,
the fifth distance is different from the first distance and the second distance,
the sixth distance is different from the first distance and the second distance,
a seventh distance is from the fourth detector structure to the first source structure,
an eighth distance is from the fourth detector structure to the second source structure,
the seventh distance is different from the first, second, and fifth distances,
the eighth distance is different from the first, second, fifth, and sixth distances,
the first distance is greater than each of the second, third, sixth, seventh, and eighth distances, and
the second distance is less than each of the fifth, sixth, seventh, and eight distances;
generating digital reflectance data points for the first tissue phantom from detected light detected by the first, second, third, and fourth detector structures;
comparing digital reflectance data points for a reflectance curve for the first tissue phantom and the digital reflectance data points for the first tissue phantom for the detected light detected by the first detector structure for the first and second distances, the second detector structure for the third and fourth distances, the third detector structure for the fifth and sixth distances, and the fourth detector structure for the seventh and eighth distances;
generating a set of calibration functions based on comparing the digital reflectance data points for the reflectance curve for the first tissue phantom and the digital reflectance data points for the first tissue phantom for the detected light detected by the first detector structure for the first and second distances, the second detector structure for the third and fourth distances, the third detector structure for the fifth and sixth distances, and the fourth detector structure for the seventh and eighth distances, wherein each calibration function in the set of calibration functions is associated with a unique, source structure-detector structure pair; and
storing the set of calibration functions in a memory of the tissue oximetry device.

2. The method of claim 1 wherein the first and second source structures and the first, second, third, and fourth detector structures are arranged in a circular arrangement on the probe face of the tissue oximetry device.

3. The method of claim 1 wherein the first and second, third, and fourth detector structures are arranged asymmetrically on a probe face of the tissue oximetry device.

4. The method of claim 1 wherein the first and second detector structures are arranged symmetrically about a point on a line.

5. The method of claim 4 wherein the third and fourth detector structures are arranged symmetrically about the point on the line.

6. The method of claim 5 wherein the first and second source structures and the first, second, third, and fourth detector structures are arranged in a circular arrangement and the line intersects a circle of the circular arrangement at two points.

7. The method of claim 1 wherein at least two source structure-to-detector structure distances are about 1.5 millimeters or less, and at least two source structure-to-detector structure distances are about 2.5 millimeters or greater.

8. The method of claim 7 wherein the source structure-to-detector structure distances are less than about 4 millimeters.

9. The method of claim 7 wherein the source structure-to-detector structure distances are less than about 10 millimeters.

10. The method of claim 1 wherein the first, second, third, and fourth detector structures are arranged in a circular arrangement and the first and second source structures are arrangement along a line that intersects that circle at two locations.

11. The method of claim 10 wherein the line bisects the circle.

12. The method of claim 10 wherein the line does not intersect detector locations of the detector structures on the circle.

13. The method of claim 1 wherein the second distance is the same as the third distance.

14. The method of claim 13 where the first distance is the same as the fourth distance.

15. The method of claim 1 wherein the second distance is approximately the same as the third distance.

16. The method of claim 15 wherein the first distance is approximately the same as the fourth distance.

17. The method of claim 1 comprising:
making an oxygen saturation measurement; and
correcting the oxygen saturation measurement using the set of calibration functions.

18. The method of claim 1 wherein each of the calibration functions comprises at least one factor.

19. The method of claim 18 comprising:
averaging the factors for the given one of the first, second, third, and fourth detector structures if the factors for the a given one of the first, second, third, and fourth detector structures differ by a threshold amount; and
storing an average of the factors in the memory.

20. A method comprising:
repeating the steps of claim 1 for at least a second tissue phantom, wherein the set of calibration functions are for the first tissue phantom and the second tissue phantom.

Assignees

• Vioptix Inc

Inventors

• Bechtel Kate Leeann
• Wilfley Brian

Classifications

• A61B5/1495 Primary

  Calibrating or testing of in-vivo probes · CPC title

• A61M35/003

  Portable hand-held applicators having means for dispensing or spreading integral media (hand-held massage devices with liquid delivery A61H7/003) · CPC title

• A61B2090/395

  with marking agent for marking skin or other tissue · CPC title

• A61B5/7475

  User input or interface means, e.g. keyboard, pointing device, joystick · CPC title

• A61B5/1459

  invasive, e.g. introduced into the body by a catheter · CPC title