Method and system for optical coherence elastography of posterior parts of the eye

Patent metadata

Field	Value
Publication number	US-9498120-B2
Application number	US-201414579678-A
Country	US
Kind code	B2
Filing date	Dec 22, 2014
Priority date	Dec 22, 2014
Publication date	Nov 22, 2016
Grant date	Nov 22, 2016

Abstract

A system and method for optical coherence elastography of tissue of an eye. The method includes introducing a probe into the eye, the probe including a vibration element, generating time resolved images of the tissue of the eye located posterior the vibration element of the probe by optical coherence tomography, exciting the vibration element to ultrasonic vibrations making the tissue vibrate or oscillate, measuring a displacement of the tissue in the time resolved images, and calculating elasticity values of the tissue from the displacement.

First claim

What is claimed is:

1. A method for optical coherence elastography of a tissue of an eye, the method comprising:
introducing at least a portion of a probe into a vitreous humor of the eye, the portion of the probe comprising a vibration element;
generating time resolved images of the tissue of the eye, the tissue being located more posterior than the vibration element of the probe, wherein the time resolved images of the tissue are generated by optical coherence tomography;
exciting the vibration element to ultrasonic vibrations making the tissue vibrate or oscillate;
measuring a displacement of the tissue in the time resolved images; and
calculating elasticity values of the tissue from the displacement.

2. The method of claim 1 , wherein the time resolved images of the tissue are sectional images of the tissue.

3. The method of claim 1 , further comprising:
determining a distance between the vibration element of the probe and the tissue;
determining a force applied to the tissue on basis of the distance and at least on parameter describing the ultrasonic vibrations; and
determining an original length the tissue has prior to the exititation step, wherein the displacement of the tissue is measured as a change in length of the tissue, and the elasticity values of the tissue are calculated from the force applied and a ratio of the change in length and the original length.

4. The method of claim 1 , wherein the tissue is a retina of the eye.

5. The method of claim 4 , wherein the time resolved images and the elasticity values are generated as a map of the retina.

6. The method of claim 1 , wherein the probe is a surgical instrument.

7. The method of claim 6 , wherein the surgical instrument is a vitrectomy instrument.

8. The method of claim 1 , wherein the displacement of the tissue is measured by speckle tracking in the time resolved images or by cross correlation of the time resolved images.

9. A system for optical coherence elastography of a tissue of an eye, the system comprising:
a probe adapted to be introduced at least partially into the eye at a location posterior to the iris, the probe comprising a vibration element adapted to be located in a vitreous humor of the eye;
a surgical microscope imaging the tissue and comprising an optical coherence tomograph generating time resolved images of the tissue of the eye the tissue being located more posterior than the vibration element of the probe, wherein time resolved images are generated by optical coherence tomography; and
a computing and controlling device connected to the probe and to the surgical microscope and which device is adapted to control the vibration element to perform ultrasonic vibrations making the tissue vibrate or oscillate, to measure a displacement of the tissue in the time resolved images, and to calculate elasticity values of the tissue from the displacement.

10. The system of claim 9 , wherein the tissue is a retina of the eye and the surgical microscope comprises a retina motion compensation and stabilization unit.

11. The system of claim 9 , wherein surgical microscope generates the time resolved images as time resolved sectional images of the tissue.

12. The system of claim 9 , wherein the computing and controlling device determines a distance between the vibration element of the probe and the tissue, determines a force applied to the tissue on basis of the distance and at least one parameter describing the ultrasonic vibrations, determines an original length the tissue has prior to excitation, measures the displacement of the tissue as a change in length of the tissue, and calculates the elasticity values of the tissue from the force applied and a ratio of the change in length and the original length.

13. The system of claim 9 , wherein the surgical microscope images a retina of the eye.

14. The system of claim 13 , wherein the surgical microscope generates the time resolved images as a map of the retina and wherein the computing and controlling device generates the elasticity values as a map of the retina.

15. The system of claim 14 , further comprising a display unit for visualizing a microscopic view overlaid by the elasticity values.

16. The system of claim 9 , wherein the probe is a surgical instrument.

17. The system of claim 16 , wherein the surgical instrument is a vitrectomy instrument.

18. The system of claim 9 , wherein the computing and controlling device measures the displacement of the tissue by speckle tracking in the time resolved images or by cross correlation of the time resolved images.

Assignees

• Eslami Abouzar
• Maier-Matic Corinna
• Hartwig Falk
• Kochwagner Christine
• Zeiss Carl Meditec Ag

Inventors

• Eslami Abouzar
• Maier-Matic Corinna
• Hartwig Falk
• Kochwagner Christine

Classifications

• A61B8/485

  involving measuring strain or elastic properties · CPC title

• A61F9/00736

  Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments (A61F9/008 takes precedence) · CPC title

• A61B3/0025

  characterised by electronic signal processing, e.g. eye models · CPC title

• A61B5/0051

  by applying vibrations · CPC title

• A61B3/12

  for looking at the eye fundus, e.g. ophthalmoscopes (A61B3/13 takes precedence) · CPC title