Liquid enteral nutritional composition with a low monovalent metal ion content

Patent metadata

Field	Value
Publication number	US-9497983-B2
Application number	US-201013376098-A
Country	US
Kind code	B2
Filing date	Jun 7, 2010
Priority date	Jun 5, 2009
Publication date	Nov 22, 2016
Grant date	Nov 22, 2016

Abstract

Heat-treated liquid enteral nutritional composition with a low monovalent metal ion content are provided that contain micellar casein and optionally caseinate, and in which the total amount of monovalent metal ions is less than 25 mg/g of protein. Also, heat-treated liquid enteral nutritional compositions are disclosed comprising 10 to 20 g of protein per 100 ml of the composition, in which all or a major part of said protein comprises micellar casein. Also, a method is disclosed for producing the composition according to the invention, comprising a step wherein an aqueous protein solution in which all or a major part of said protein comprises micellar casein, is subjected to an evaporation step.

First claim

The invention claimed is:

1. A heat-treated liquid enteral nutritional composition comprising (a) 10 to 20 g of protein per 100 ml of the composition, (b) less than or equal to 10 weight % of whey protein, and (c) between 170 and 600 mg calcium per 100 ml of the composition, in which at least 70 weight % of the protein comprises micellar casein, the total amount of monovalent metal ions in the composition is less than 25 mg/g of protein, and the viscosity of the composition is lower than 200 mPa·s as measured at a shear rate of 100 s −1 at 20° C. using a rotational viscosity meter using a cone/plate geometry.

2. The heat-treated liquid enteral nutritional composition according to claim 1 , wherein the total amount of monovalent metal ions is less than 20 mg/g of protein.

3. The heat-treated liquid enteral nutritional composition according to claim 1 , wherein the total amount of monovalent metal ions is between 5 and 25 mg/g of protein.

4. The heat-treated liquid enteral nutritional composition according to claim 1 , wherein the monovalent metal ions comprise sodium ions, potassium ions, or both.

5. The heat-treated liquid enteral nutritional composition according to claim 1 , in which at least 80 weight % of the protein comprises micellar casein.

6. The heat-treated liquid enteral nutritional composition according to claim 1 , in which the protein provides 10% to 100% of the total energy content of the composition.

7. The heat-treated liquid enteral nutritional composition according to claim 1 , wherein the protein comprises at most 30 weight % of caseinate, based on the total weight of the protein.

8. The heat-treated liquid enteral nutritional composition according to claim 7 , wherein micellar casein and caseinate comprise at least 95 weight % of the total protein.

9. The heat-treated liquid enteral nutritional composition according to claim 7 , wherein the caseinate is a divalent ion-caseinate.

10. The heat-treated liquid enteral nutritional composition according to claim 1 , further comprising fat, digestible carbohydrates, non-digestible carbohydrates, or a combination thereof.

11. The heat-treated liquid enteral nutritional composition according to claim 10 , wherein the fat provides between 10 to 70% of the total energy content of the composition.

12. The heat-treated liquid enteral nutritional composition according to claim 10 , wherein the fat comprises a source of long chain fatty acids.

13. The heat-treated liquid enteral nutritional composition according to claim 10 , wherein the digestible carbohydrates provide between 30 to 60% of the total energy content of the composition.

14. The heat-treated liquid enteral nutritional composition according to claim 1 , wherein the composition is in the form of a 125 ml unit dosage.

15. The heat-treated liquid enteral nutritional composition according to claim 1 , having (a) an energy density of about 1.0 to 3.5 kcal/ml, and (b) a micellar casein to caseinate weight ratio of about 80:20 to 100:0, and comprising about 14 to 16 g of protein per 100 ml of the composition, wherein the protein provides 20 to 40% of the total energy content of the composition.

16. The heat-treated liquid enteral nutritional composition according to claim 1 , having (a) an energy density of about 2.4 kcal/ml, and (b) a micellar casein to caseinate weight ratio about 80:20 to 100:0, and comprising about 15 g of protein per 100 ml of the composition, wherein:
(i) protein provides about 25% of the total energy content of the composition;
(ii) fat provides about 35% of the total energy content of the composition; and
(iii) carbohydrate provides about 40% of the total energy content of the composition.

17. A method of providing nutrition, comprising administering to a person in need thereof the nutritional composition according to claim 1 .

18. The method according to claim 17 , wherein the person is an elderly person, a person that is in a disease state, a person that is recovering from a disease state, or a person that is malnourished.

19. A heat-treated semi-solid enteral nutritional composition comprising 10 to 20 g of protein per 100 ml of the composition and a thickener or gelling agent, in which at least 70 weight % of the protein comprises micellar casein, and in which the total amount of monovalent metal ions in the composition is less than 25 mg/g of protein.

20. The heat-treated semi-solid nutritional composition according to claim 19 , in the form of a pudding, a custard, a soup, an ice cream, and a gelly.

21. The heat-treated liquid enteral nutritional composition according to claim 1 , comprising 12 to 20 g of protein per 100 ml of the composition.

22. A heat-treated liquid enteral nutritional composition, comprising (a) 10 to 20 g of protein per 100 ml of the composition, (b) between 170 and 600 mg calcium per 100 ml of the composition, wherein the protein comprises micellar casein isolate and milk protein isolate, the total amount of monovalent metal ions in the composition is less than 25 mg/g of protein, and the viscosity of the composition is lower than 200 mPa·s as measured at a shear rate of 100 s −1 at 20° C. using a rotational viscosity meter using a cone/plate geometry.

Assignees

• Minor Marcel
• Van Steenis Suzanne
• Ruis Hilde
• Nutricia Nv

Inventors

• Minor Marcel
• Van Steenis Suzanne
• Ruis Hilde

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61P1/00

  Drugs for disorders of the alimentary tract or the digestive system · CPC title

• A61K38/1709 Primary

  from mammals · CPC title

• A61K9/0053

  Mouth and digestive tract, i.e. intraoral and peroral administration · CPC title

• A61K9/1075

  Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence) · CPC title