Polymer particle containing fluorescent molecule and method for producing the same

Patent metadata

Field	Value
Publication number	US-9494580-B2
Application number	US-200913060882-A
Country	US
Kind code	B2
Filing date	Sep 10, 2009
Priority date	Sep 11, 2008
Publication date	Nov 15, 2016
Grant date	Nov 15, 2016

Abstract

Polymer particles are provided which contain fluorescent molecules with high presence ratio in a polymer layer thereof and a method for preparing thereof. Polymer particles are swelled in a non-aqueous solution excluding exclusively water preferably promotes selling of the polymer layer and transfer of the fluorescent molecules to the polymer layer could not protected by water molecules such that much more fluorescent molecule may be introduced into inside of the polymer layer. Furthermore, since the water is added to the reaction system prior to evaporation removal of the non-aqueous solvent, dry-up of the polymer particles is prevented by the water remained in the reaction system and the polymer particles including fluorescent molecules with high presence ratio of the fluorescent molecules preferably keep high dispersibility using the above described procedures.

First claim

The invention claimed is:

1. A polymer magnetic particle comprising:
a magnetic core;
a coating polymer layer on the magnetic core; and
a fluorescent compound being soluble in a non-aqueous solvent as a non-crystal state, the fluorescent compound being adsorbed and localized in the coating polymer layer as the non-crystal state at a concentration at least 100 nmol per 1 mg of the polymer magnetic particles.

2. The polymer magnetic particle of claim 1 , wherein the fluorescent compound possesses hydrophobicity.

3. The polymer magnetic particle of claim 2 , wherein the fluorescent compound further comprises a rare earth element.

4. The polymer magnetic particle of claim 3 , wherein the rare earth element is selected form the group consisting of europium, samarium, terbium, and dysprosium.

5. The polymer magnetic particle of claim 1 , wherein the fluorescent compound is a rare earth metal chelate complex.

Assignees

• Handa Hiroshi
• Hatakeyama Mamoru
• Sakamoto Satoshi
• Mochizuki Yusuke
• Kawada Shintaro
• Tokyo Inst Tech

Inventors

• Handa Hiroshi
• Hatakeyama Mamoru
• Sakamoto Satoshi
• Mochizuki Yusuke
• Kawada Shintaro

Classifications

• G01N33/533 Primary

  with fluorescent label · CPC title

• C08J2327/12

  containing fluorine atoms · CPC title

• C08J3/128

  Polymer particles coated by inorganic and non-macromolecular organic compounds · CPC title

• H01F1/09

  mixtures of metallic and non-metallic particles; metallic particles having oxide skin · CPC title

• H01F1/06

  in the form of particles, e.g. powder (H01F1/047 takes precedence {; record carriers G11B5/70605}) · CPC title