Microphthalmia-associated transcription factor-derived peptide and composition containing same

Patent metadata

Field	Value
Publication number	US-9493528-B2
Application number	US-201414759277-A
Country	US
Kind code	B2
Filing date	Jan 7, 2014
Priority date	Jan 10, 2013
Publication date	Nov 15, 2016
Grant date	Nov 15, 2016

Abstract

Provided are small peptide fragments derived from microphthalmia-associated transcription factor (MITF) and a method for preventing or treating melanoma using the same as an active ingredient. Further provided is a method for skin-whitening and/or for inhibiting skin pigmentation, using the peptide fragments as an active ingredient.

First claim

The invention claimed is:

1. A peptide inhibiting microphthalmia-associated transcription factor-mediated transcription, as set forth by SEQ ID NO: 1 or SEQ ID NO: 3.

2. A method for treating melanoma, comprising administering an effective amount of a peptide selected from the group consisting of the peptide of SEQ ID NO: 1, the peptide of SEQ ID NO: 2, the peptide of SEQ ID NO: 3 and the peptide of SEQ ID NO: 4 to a patient suffering from melanoma.

3. A method for skin-whitening, comprising administering an effective amount of a peptide selected from the group consisting of the peptide of SEQ ID NO: 1, the peptide of SEQ ID NO: 2, the peptide of SEQ ID NO: 3 and the peptide of SEQ ID NO: 4 to a subject in need thereof.

4. A method for inhibiting skin pigmentation, comprising administering an effective amount of a peptide selected from the group consisting of the peptide of SEQ ID NO: 1, the peptide of SEQ ID NO: 2, the peptide of SEQ ID NO: 3 and the peptide of SEQ ID NO: 4 to a subject in need thereof.

5. A method for inhibiting a skin pigmentation induced by exposure to ultraviolet radiation, comprising administering an effective amount of a peptide selected from the group consisting of the peptide of SEQ ID NO: 1, the peptide of SEQ ID NO: 2, the peptide of SEQ ID NO: 3 and the peptide of SEQ ID NO: 4 to a subject in need thereof.

Assignees

• Knu Industry Cooperation Found
• Supadelixir Inc

Inventors

• Park Kyeong-Han
• Hahn Jang-Hee
• Lim Dong-Young

Classifications

• C07K14/4703 Primary

  Inhibitors; Suppressors · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• A61Q19/02

  for chemically bleaching or whitening the skin · CPC title

• A61K8/64

  Proteins; Peptides; Derivatives or degradation products thereof · CPC title