Diazaspirocycloalkane and azaspirocycloalkane

Patent metadata

Field	Value
Publication number	US-9493486-B2
Application number	US-201414569564-A
Country	US
Kind code	B2
Filing date	Dec 12, 2014
Priority date	Jun 13, 2012
Publication date	Nov 15, 2016
Grant date	Nov 15, 2016

Abstract

The invention provides novel compounds having the general formula (I)

wherein R 1 , R 2 , Y and W are as described herein, compositions including the compounds and methods of using the compounds.

First claim

The invention claimed is:

1. A compound of formula (I)

wherein
R 1 is phenylalkyl substituted with R 8 , R 9 and R 10 ;
R 2 is —C(O)—R 3 ;
Y is —OC(O)—;
W is

R 3 is;

and
R 8 , R 9 , and R 10 are independently selected from H, alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, cycloalkoxy, cycloalkoxyalkyl, cycloalkylalkoxyalkyl, alkoxy, alkoxyalkyl, haloalkoxy, haloalkoxyalkyl, alkoxyalkoxy, alkoxyalkoxyalkyl, halogen, hydroxy, cyano, alkylsulfonyl, cycloalkylsulfonyl, substituted aminosulfonyl, substituted amino and substituted aminoalkyl, wherein substituted aminosulfonyl, substituted amino and substituted aminoalkyl are substituted on the nitrogen atom with one to two substituents independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl and cycloalkylcarbonyl;
or a pharmaceutically acceptable salt thereof.

2. A The compound of claim 1 , wherein R 8 is haloalkoxy, halogen or alkylsulfonyl.

3. A The compound of claim 1 , wherein R 9 is alkyl, haloalkyl or halogen.

4. The compound of claim 1 , wherein R 10 is H.

5. The compound of claim 1 , selected from:

6. The compound of claim 5 , selected from:

Assignees

• Hoffmann La Roche
• Hoffmann-La Roches Inc

Inventors

• Hunziker Daniel
• Mattei Patrizio
• Mauser Harald
• Prunotto Marco
• Ullmer Christoph

Classifications

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61P13/12

  of the kidneys · CPC title