Sarm1 enzyme activity inhibitor and application thereof
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Treatment of cancer with TOR kinase inhibitors
US9493466B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9493466-B2 |
| Application number | US-201213654441-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 18, 2012 |
| Priority date | Oct 19, 2011 |
| Publication date | Nov 15, 2016 |
| Grant date | Nov 15, 2016 |
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Abstract
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Provided herein are methods for treating or preventing a solid tumor, non-Hodgkin lymphoma or multiple myeloma in a patient, comprising administering an effective amount of a TOR kinase inhibitor to a patient having a solid tumor, non-Hodgkin lymphoma or multiple myeloma.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for treating a solid tumor, comprising administering an effective amount of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-(trans-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, to a patient having a solid tumor, wherein the solid tumor is non-small cell lung cancer or breast cancer, and wherein the solid tumor is rapamycin resistant. 2. The method of claim 1 , wherein the solid tumor is an advanced solid tumor. 3. The method of claim 1 , wherein the breast cancer is ER+/Her2-, ER+/Her2+, ER-/Her2+ or triple negative (TN). 4. The method of claim 1 , wherein the solid tumor is non-small cell lung cancer. 5. The method of claim 1 , wherein the solid tumor is breast cancer.
Assignees
Inventors
Classifications
- A61K31/4985Primary
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems · CPC title
Antineoplastic agents · CPC title
Ortho-condensed systems · CPC title
- C07D487/04Primary
Ortho-condensed systems · CPC title
Ortho-condensed systems · CPC title
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- What does patent US9493466B2 cover?
- Provided herein are methods for treating or preventing a solid tumor, non-Hodgkin lymphoma or multiple myeloma in a patient, comprising administering an effective amount of a TOR kinase inhibitor to a patient having a solid tumor, non-Hodgkin lymphoma or multiple myeloma.
- Who is the assignee on this patent?
- Signal Pharm Llc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/4985. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 15 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).