Super-hydrophilic structures

Patent metadata

Field	Value
Publication number	US-9492952-B2
Application number	US-201213435544-A
Country	US
Kind code	B2
Filing date	Mar 30, 2012
Priority date	Aug 30, 2010
Publication date	Nov 15, 2016
Grant date	Nov 15, 2016

Abstract

A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 μm to about 3 μm, and heights from about 2 μm to about 20 μm from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.

First claim

What is claimed:

1. A polydioxanone film comprising polydioxanone pillars having circular cross-sections integrally molded with and extending from the surface of at least one side of said film, said pillars having diameters from about 0.2 μm to about 3 μm, and heights of from about 2 μm to about 20 μm from the surface of the film, wherein the polydioxanone pillars demonstrate super-hydrophilicity.

2. The polydioxanone film of claim 1 , wherein the pillars are treated with an oxygen plasma to increase the oxygen content of said polydioxanone pillars, relative to untreated polydioxanone pillars.

3. The polydioxanone film of claim 2 , wherein the polydioxanone pillars have heights of about 20 μm from the surface of the film, having a static water contact angle of less than about 10°.

4. The polydioxanone film of claim 1 , wherein the polydioxanone pillars have diameters from about 0.6 μm to about 1 μμm, heights of about 20 μm from the surface of the film, having a static water contact angle of less than about 10°.

5. The polydioxanone film of claim 1 , which has a protein adsorption capacity from about 2.5 μg/cm 2 to about 6.0 μg/cm 2 of the film surface.

6. The polydioxanone film of claim 5 , which has a protein adsorption capacity from about 4.0 μg/cm 2 to about 6.0 μg/cm 2 of the film surface.

7. A process for adsorbing proteins, comprising exposing a protein-containing solution to a polydioxanone film comprising polydioxanone pillars having circular cross-sections integrally molded with and extending from the surface of at least one side of said film, said pillars having diameters from about 0.2 μm to about 3 μm, and heights from about 2 μm to about 20 μm from the surface of the film, wherein the polydioxanone pillars demonstrate super-hydrophilicity.

8. The process of claim 7 , wherein the pillars are treated with an oxygen plasma to increase the oxygen content of said polydioxanone pillars, relative to untreated polydioxanone pillars.

9. The process of claim 7 , wherein the polydioxanone pillars have diameters from about 0.6 μm to about 1 μm, heights of about 20 μm from the surface of the film, having a static water contact angle of less than about 10°.

10. The process of claim 8 , wherein the polydioxanone pillars have heights of about 20 μm from the surface of the film, having a static water contact angle of less than about 10°.

11. The process of claim 7 , wherein the polydioxanone film has a protein adsorption capacity from about 2.5 μg/cm 2 to about 6.0 μg/cm 2 of the film surface.

12. The process of claim 11 , wherein the polydioxanone film has a protein adsorption capacity from about 4.0 μg/cm 2 to about 6.0 μg/cm 2 of the film surface.

13. A medical device comprising a polydioxanone film comprising polydioxanone pillars having circular cross-sections integrally molded with and extending from the surface of at least one side of said film, said pillars having a diameter from about 0.2 μm to about 3 μm, and a height of up to about 2 μm to about 20 μm from the surface of the film, wherein the polydioxanone pillars demonstrate super-hydrophilicity.

14. The medical device of claim 13 , which has improved biocompatibility as compared to an implant device without said film.

15. The medical device of claim 13 , which has an increased capacity for protein adsorption as compared to a flat polydioxanone film.

Assignees

• Luong-Van Emma Kim
• Rodriguez Isabel
• Low Hong Yee
• Elmouelhi Noha
• Cooper Kevin
• Natarajan Sriram
• Vyakarnam Murty N
• Lim Chee Tiong
• Endo-Surgery Inc
• Agency Science Tech & Res

Inventors

• Luong-Van Emma Kim
• Rodriguez Isabel
• Low Hong Yee
• Elmouelhi Noha
• Cooper Kevin
• Natarajan Sriram
• Vyakarnam Murty N
• Lim Chee Tiong

Classifications

• A61L31/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} · CPC title

• B29C33/52 Primary

  soluble or fusible {(in particular used in injection moulding B29C45/4457)} · CPC title

• A61B2017/00951

  adhesive · CPC title

• A61B2017/00938

  hydrophobic · CPC title

• A61B2017/00942

  hydrophilic · CPC title