Ligand graft functionalized substrates

Patent metadata

Field	Value
Publication number	US-9492771-B2
Application number	US-56257309-A
Country	US
Kind code	B2
Filing date	Sep 18, 2009
Priority date	Sep 19, 2008
Publication date	Nov 15, 2016
Grant date	Nov 15, 2016

Abstract

Polyethyleneimine and polyalkylene biguanide ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.

First claim

What is claimed is:

1. An article comprising a substrate and extending from the surfaces thereof:
grafted polyethyleneimine ligand groups forming a ligand-functionalized substrate;
wherein the polyethyleneimine ligand groups are one or more of the formula:

wherein:
“˜” is a divalent linking group grafted to the surface of the substrate and the polyethyleneimine ligand group,
x may be zero and y is at least 1, and x+y is 2 to 50; and

grafted quaternary ammonium groups on the surface of the substrate.

2. An article comprising a porous base substrate having interstitial and outer surfaces, grafted quaternary ammonium groups, and grafted ligand groups extending from the surfaces of the porous base substrate thereby forming a ligand-functionalized substrate; wherein the grafted ligand groups comprises the reaction product of a grafted electrophilic functional group and a ligand compound:

wherein x is zero, y is at least 1, and x+y is 2 to 2000.

3. An article comprising a substrate and extending from the surfaces thereof grafted polyethyleneimine ligand groups and grafted quaternary ammonium groups, thereby forming a ligand-functionalized substrate;
wherein the polyethyleneimine ligand groups are one or more of the formula:

wherein:
“˜” is a divalent linking group grafted to the surface of the substrate and the polyethyleneimine ligand group,
x may be zero and y is at least 1, and x+y is 2 to 50;

wherein the ligand-functionalized substrate has enhanced binding selectivity for host cell proteins, DNA, RNA, and viruses relative to antibodies; and
wherein the article yields a log-reduction value (LRV) of at least 5.0 for neutral viruses disposed in a solution comprising from 0 to about 150 mM salt.

Assignees

• Etzel Mark R
• Seshadri Kannan
• Rasmussen Jerald K
• Waller Jr Clinton P
• Weiss Douglas E
• He Yi
• 3M Innovative Properties Co

Inventors

• Etzel Mark R
• Seshadri Kannan
• Rasmussen Jerald K
• Waller Jr Clinton P
• Weiss Douglas E
• He Yi

Classifications

• C08J2327/14

  Homopolymers or copolymers of vinyl fluoride · CPC title

• Y10T428/249991

  Synthetic resin or natural rubbers · CPC title

• Y10T442/60

  Nonwoven fabric [i.e., nonwoven strand or fiber material] · CPC title

• Y10T428/2935

  Discontinuous or tubular or cellular core · CPC title

• Y10T442/2525

  Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.] · CPC title