Concentrate for a dialysis liquid and dialysis liquid made from it

Patent metadata

Field	Value
Publication number	US-9492602-B2
Application number	US-201313761245-A
Country	US
Kind code	B2
Filing date	Feb 7, 2013
Priority date	Feb 8, 2012
Publication date	Nov 15, 2016
Grant date	Nov 15, 2016

Abstract

Concentrate for a dialysis liquid, at least comprising one acid and one physiologically acceptable electrolyte, characterized in that the acid comprises at least one acidic ion exchanger or is an acidic ion exchanger.

First claim

The invention claimed is:

1. A concentrate for a dialysis liquid, the concentrate comprising an acid and a physiologically acceptable electrolyte, characterized in that the acid comprises an acidic ion exchanger, wherein the acidic ion exchanger comprises one or more members selected from the set consisting of sulfonate groups, sulfate groups, phosphate groups, phosphonate groups, and carboxylate groups wherein the groups are bound to a cross-linked polystyrene or poly(meth)acrylate, and wherein the concentrate is provided in a container and the ion exchanger and the physiologically acceptable electrolyte are provided in the form of a mixture in said container, where in the container is accessible to water or a sodium chloride solution, in order to release protons from the acidic ion exchanger.

2. The concentrate according to claim 1 , wherein the physiologically acceptable electrolyte comprises one or more cations selected from the set consisting of magnesium, calcium, potassium, and sodium and one or more anions selected from the set consisting of chloride, acetate, and lactate.

3. The concentrate according to claim 1 , wherein the concentrate is provided as dry concentrate.

4. A method of making a dialysis liquid comprising at least one concentrate for a dialysis liquid according to claim 1 , and water, comprising at least step (i):
(i) mixing the concentrate according to claim 1 with water.

5. A dialysis device, comprising the concentrate provided in the container according to claim 1 , wherein the container is inserted into the dialysis device or into a device which is connected to said dialysis device and wherein the container is accessible to water.

6. The method of claim 4 , further comprising, subsequently to step (i), step (ii):
(ii) regenerating the acidic ion exchanger after the release of protons, which has been obtained after step (i).

7. A method of dialyzing blood, the method comprising at least steps (i) and (ii):
(i) mixing the concentrate according to claim 1 with water in order to make a dialysis liquid;
(ii) passing the dialysis liquid made in step (i) through a dialyzer, where it is brought into contact with blood.

Assignees

• Fresenius Medical Care Deutschland Gmbh

Inventors

• Terpin Andreas
• Nier Volker

Classifications

• A61P7/08

  Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) · CPC title

• A61K9/08

  Solutions {(composition of solutions A61K47/00)} · CPC title

• A61K33/42

  Phosphorus; Compounds thereof · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title

• A61K31/19

  Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) · CPC title