Method for producing a protein comprising composition with reduced digestive coagulation

Patent metadata

Field	Value
Publication number	US-9492502-B2
Application number	US-201314413685-A
Country	US
Kind code	B2
Filing date	Jul 9, 2013
Priority date	Jul 9, 2012
Publication date	Nov 15, 2016
Grant date	Nov 15, 2016

Abstract

A process of producing a composition comprising at least two different proteins is disclosed, of which at least one is a coagulating protein, such as a casein and/or a caseinate, and at least one is an anti-coagulating protein, such as a leguminous protein (for example pea and/or soy) combined or not with whey protein, comprising the steps of: a) heat-sterilizing a first liquid component comprising the coagulating protein, b) heat-sterilizing a second liquid component comprising the anti-coagulating protein, and c) mixing the first component with the second component to obtain a mixture thereof. The obtained mixture is useful as a food constituent having reduced coagulation in the upper gastro-intestinal tract, more in particular in the stomach.

First claim

The invention claimed is:

1. A process of producing a composition comprising a mixture of at least two different proteins, of which at least one is a coagulating protein and at least one is an anti-coagulating protein, the process comprising:
(a) heat-sterilising a first liquid component comprising the coagulating protein,
(b) heat-sterilising a second liquid component comprising the anti-coagulating protein, and
(c) mixing the first component with the second component to obtain a mixture of the proteins,
wherein (a) and (b) are performed separately,
wherein the mixture has a weight ratio of the coagulating protein to the anti-coagulating protein between 20:1 and 1:1, and wherein the mixture of coagulating and anti-coagulating protein, in the Gastric Digestion Test of Example 1, produces an amount of wet weight coagulate fraction larger than 0.25 mm which is at least 10% less than the amount produced by the same protein mixture prepared by first mixing the two different proteins followed by heat-sterilising the mixed proteins.

2. The process according to claim 1 , wherein the first and/or the second liquid component further comprises a lipid.

3. The process according to claim 2 , wherein the lipid is selected from a vegetable oil, animal fat and fish oil.

4. The process according to claim 1 , wherein the coagulating protein is a casein selected from the group consisting of micellar casein, non-micellar casein, sodium caseinate, calcium caseinate, potassium caseinate and magnesium caseinate.

5. The process according to claim 1 , wherein the anti-coagulating protein is a non-dairy protein which is an anti-coagulating protein according to the Gastric Digestion Test of Example 1, and/or a combination of such non-dairy protein with whey protein.

6. The process according to claim 1 , wherein the mixture has a weight ratio of the coagulating protein to the anti-coagulating protein of between 19:1 and 1:1.

7. The process according to claim 1 , further comprising homogenising the first and/or second liquid component.

8. The process according to claim 1 , further comprising, before mixing (c), drying the heat-sterilised first liquid component and/or the heat-sterilised second liquid component to obtain a powder.

9. The process according to claim 1 , further comprising (d) drying the mixture to obtain a powder.

10. The process according to claim 1 , further comprising adding at least 1 wt % of one or more lipids and carbohydrates, relative to the total dry weight of the mixture; and/or at least 0.1 wt % of dietary fibres, relative to the total dry weight of the mixture; or a combination thereof, to the components when heat-sterilizing the first liquid component and/or when heat-sterilising the second liquid component, and/or while mixing the first component with the second component.

11. The process according to claim 10 , further comprising adding at least 10 wt % of one or more lipids and carbohydrates, relative to the total dry weight of the mixture; and/or at least 1 wt % of dietary fibres, relative to the total dry weight of the mixture; or a combination thereof, to the components when heat-sterilizing the first liquid component and/or when heat-sterilising the second liquid component, and/or while mixing the first component with the second component.

12. The process according to claim 1 , wherein the first liquid component comprises less than 15 wt % anti-coagulating protein.

13. The process according to claim 1 , wherein the anti-coagulating protein is selected from Fabaceae proteins.

14. The process according to claim 1 , wherein the anti-coagulating protein is a pea protein or a soybean protein.

15. A dry or liquid composition obtained by the process according to claim 1 .

16. A method for reducing, preventing or treating gastrointestinal reflux, intestinal discomfort, reflux, aspiration pneumonia, high gastric residual volume, vomiting, nausea, bloating, digestive discomfort, gastrointestinal cramping, colics, coagulation in the upper gastrointestinal tract and/or delayed gastric emptying, the method comprising administering to a subject in need thereof a composition obtained by the process of claim 1 .

17. A method for reducing or preventing coagulation in the upper gastrointestinal tract in a person, the method comprising administering to the person a composition obtained by the process of claim 1 .

Assignees

• Nutricia Nv
• Nutricia Nv

Inventors

• Van Den Braak Claudia Catharina Maria
• Ludwig Thomas
• Minor Marcel
• Verdurmen Rudolph Eduardus Maria
• Ruis Hilde

Classifications

• A61K38/011

  from plants · CPC title

• A61K38/018

  from milk · CPC title

• A61K9/0095

  Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006) · CPC title

• A23L33/19

  Dairy proteins · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title