Iron oxide nanoparticles for use in treating non-infectious inflammatory disorders

Patent metadata

Field	Value
Publication number	US-9492480-B2
Application number	US-201113640843-A
Country	US
Kind code	B2
Filing date	Apr 12, 2011
Priority date	Apr 12, 2010
Publication date	Nov 15, 2016
Grant date	Nov 15, 2016

Abstract

In accordance with the present disclosure there are provided iron oxide nanoparticles for use in the treatment of non-infectious inflammatory disorders. Also provided by the present disclosure is a method of treatment of non-infectious inflammatory disorders making use of such particles, pharmaceutical compositions and kits comprising such particles.

First claim

The invention claimed is:

1. A method for treating myocardial infarction in a human subject suffering from myocardial infarction, the method comprising:
administering to the subject in need an amount of an active agent effective to treat myocardial infarction, said active agent being iron oxide nanoparticles,
wherein said method does not include a step of magnetic resonance imaging of myocardial infarction using iron oxide particles.

2. The method of claim 1 , wherein the iron oxide nanoparticles are in naked form, surface modified, or formulated within a carrier.

3. The method of claim 1 , wherein the iron comprises one or both of ferric iron (Fe 3+ ) and ferrous iron (Fe 2+ ).

4. The method of claim 1 , wherein the iron oxide is selected from the group consisting of magnetic iron oxide, ferromagnetic iron oxide, ferrimagnetic iron oxide and anti-ferromagnetic iron oxide.

5. The method of claim 1 , wherein the iron oxide is superparamagnetic iron oxide.

6. The method of claim 1 , wherein the iron oxide nanoparticles are modified with an organic material selected from the group consisting of small molecules, surfactants, polymers and biomolecules.

7. The method of claim 1 , wherein the iron oxide nanoparticles are modified with an inorganic material selected from the group consisting of silica, metal substance, nonmetal elementary substance, metal oxides and metal sulfides.

8. The method of claim 1 , wherein the iron oxide nanoparticles are in the form selected from the group consisting of an iron oxide core within a shell of organic or inorganic material; a mosaic form; a core of organic or inorganic material within a shell of iron oxide; a shell-core-shell form; and a bi-functional dumbbell form.

9. The method of claim 1 , wherein the iron oxide nanoparticles are embedded within a polymeric shell coating or encapsulated within a core or a lipid-based vesicle.

10. The method of claim 9 , wherein the iron oxide nanoparticles are encapsulated within liposomes.

11. The method of claim 10 , wherein the liposomes are multilamellar vesicles (MLV).

12. The method of claim 10 , comprising a targeting moiety for targeting the liposome to a target site.

13. The method of claim 12 , wherein the targeting moiety is hyaluronic acid.

14. The method of claim 9 , wherein the polymeric shell coating comprises polymers selected from the group consisting of polysaccharide, polyethyleneglycol, dextran, siloxanes, and carboxydextran.

15. The method of claim 1 , wherein the iron oxide nanoparticles have a diameter of between 1 nm to 200 nm.

16. The method of claim 1 , wherein the iron oxide nanoparticles are administered by injection in combination with a pharmaceutical carrier.

Assignees

• Leor Jonathan
• Ben-Mordechai Tamar
• Adutler-Lieber Shimrit
• Margalit Rimona
• Elron-Gross Inbar
• Glucksam-Galnoy Yifat
• Univ Ramot
• Tel Hashomer Medical Res Infrastructure & Services Ltd

Inventors

• Leor Jonathan
• Ben-Mordechai Tamar
• Adutler-Lieber Shimrit
• Margalit Rimona
• Elron-Gross Inbar
• Glucksam-Galnoy Yifat

Classifications

• Y10S977/906

  Drug delivery · CPC title

• A61K9/127

  Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant · CPC title

• Y10S977/773

  Nanoparticle, i.e. structure having three dimensions of 100 nm or less · CPC title

• A61K9/146

  with organic macromolecular compounds · CPC title

• C01G49/02

  Oxides; Hydroxides {(C01G49/0018 takes precedence)} · CPC title