Methods and materials for stabilizing analyte sensors

Patent metadata

Field	Value
Publication number	US-9492111-B2
Application number	US-49305406-A
Country	US
Kind code	B2
Filing date	Jul 26, 2006
Priority date	Apr 22, 2002
Publication date	Nov 15, 2016
Grant date	Nov 15, 2016

Abstract

The disclosure provides a sensor including a sensor having an external surface and a cannula. The cannula comprises a substantially cylindrical wall encircling a lumen, at least one aperture and a distal end. The sensor is positioned within the lumen and the distal end of the cannula extends beyond the sensor. This configuration functions for example to stabilize chemical reactions associated with the sensor by creating a buffer zone between the sensor and the surrounding tissues at the site of implantation. In certain embodiments, the sensor can further comprise an accessory material in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the sensor. The sensor can also comprise anchors that keeps the sensor in contact with subcutaneous tissue of a subject upon insertion of the sensor into the body of the subject.

First claim

What is claimed is:

1. A sensor system comprising:
a sensor having a chemically reactive surface that reacts with an analyte to be sensed; and
a cannula comprising:
a substantially cylindrical housing that surrounds the sensor;
at least one aperture disposed in the housing that allows the analyte to diffuse therethrough so as to contact the chemically reactive surface;
an end that extends beyond an end of the sensor;
an accessory material provided in proximity to the chemically reactive surface, wherein:
the accessory material fills the at least one aperture of the cannula;
the accessory material is disposed in the aperture such that a surface of the accessory material is substantially flush with a surface of the cannula; and
the sensor system is adapted to contact a tissue such that the accessory material is configured to contact and modify a biological response of the tissue.

2. The sensor system of claim 1 , wherein the cannula comprises polyurethane.

3. The sensor system of claim 1 , wherein the biological response comprises protein deposition, inflammation or proliferation of macrophages or foreign body giant cells.

4. The sensor system of claim 1 , wherein the accessory material comprises a hydrophilic polymer.

5. The sensor system of claim 4 , wherein the hydrophilic polymer comprises polyhydroxyethylmethacrylate (PHEMA), polyurethane, polysaccharide, polyacrylamide, or polyurea.

6. The sensor system of claim 4 , further comprising an anchor that assists sensor contact with subcutaneous tissue of a subject upon insertion of the sensor into a subject.

7. The sensor system of claim 6 , wherein the anchor comprises barbs affixed to the cannula.

8. The sensor system of claim 6 , wherein the anchor expands after insertion of the sensor into the subject.

9. The sensor system of claim 1 , wherein the sensor comprises an enzymatic, molecular recognition, optochemical or electrochemical sensor.

10. The sensor system of claim 1 , wherein the sensor comprises a glucose sensor.

11. The sensor system of claim 1 , wherein the accessory material comprises a sustained release material that delivers a therapeutic agent.

12. The sensor system of claim 11 , wherein the therapeutic agent comprises an anti-inflammatory, anti-bacterial, anti-viral, anti-coagulant, anti-proliferative or disinfecting agent, or a growth factor.

13. A method of stabilizing an environment for a chemical reaction between an in vivo analyte and an enzyme that reacts with the analyte, the method comprising performing the chemical reaction using an implanted sensor system comprising:
a sensor having an chemically reactive surface comprising the enzyme; and
a cannula comprising:
a substantially cylindrical housing that encircles the sensor;
at least one aperture disposed in the housing that allows the analyte to diffuse therethrough so as to contact the chemically reactive surface; and
an end that extends beyond an end of the sensor,

wherein the aperture and the chemically reactive surface of the implanted sensor system form a stabilized chemical reaction environment that is further stabilized by the end of the cannula that extends beyond an end of the sensor, and
an accessory material provided in proximity to the chemically reactive surface, wherein:
the accessory material fills the at least one aperture of the cannula;
the accessory material is disposed in the aperture such that a surface of the accessory material is substantially flush with a surface of the cannula; and
the sensor system is adapted to contact a tissue such that the accessory material is configured to contact and modify a biological response of the tissue;
so that the environment for the chemical reaction between the in vivo analyte and the enzyme that reacts with the analyte is stabilized.

14. The method of claim 13 , wherein the environment of the chemical reaction is stabilized so as to inhibit fluctuations in the ratio between a signal generated by the analyte and signal noise not generated by the analyte.

15. The method of claim 13 , wherein the environment of the chemical reaction is stabilized so as to inhibit fluctuations in the ratio between a signal generated by the analyte and signal noise not generated by the analyte that results from the accumulation of in vivo materials at the at a site of implantation.

16. The method of claim 13 , wherein the implanted sensor system used in the method further comprises an anchor that couples the system to a site of implantation and inhibits movement of the sensor.

17. The method of claim 13 , wherein the accessory material comprises a hydrophilic polymer, an anti-inflammatory agent or a clot inhibiting agent.

18. The method of claim 13 , wherein the accessory material comprises a hydrophilic polymer.

19. The method of claim 18 , wherein the hydrophilic polymer comprises polyhydroxyethylmethacrylate (PHEMA), polyurethane, polysaccharide, polyacrylamide, or polyurea.

20. A method of delivering a biologically active substance to a subject comprising implanting a sensor system into a tissue of the subject comprising:
a sensor having chemically reactive surface that reacts with an analyte to be sensed;
an accessory material provided in proximity to the chemically reactive surface,
a cannula comprising:
a substantially cylindrical housing that surrounds the sensor;
at least one aperture disposed in the housing that allows the analyte to diffuse therethrough so as to contact the chemically reactive surface, wherein:
the accessory material fills the at least one aperture of the cannula;
the accessory material is disposed in the aperture such that a surface of the accessory material is substantially flush with a surface of the cannula; and
the sensor system is adapted to contact a tissue such that the accessory material is configured to contact and modify a biological response of the tissue; and

an end that extends beyond an end of the sensor,

wherein the accessory material comprises the biologically active substance.

21. The method of claim 20 , wherein the accessory material comprises a hydrophilic polymer.

22. The method of claim 21 , wherein the hydrophilic polymer comprises polyhydroxyethylmethacrylate (PHEMA), polyurethane, polysaccharide, polyacrylamide, or polyurea.

Assignees

• Shah Rajiv
• Soundararajan Gopikrishnan
• Van Antwerp Nannette M
• Pham Barry
• Medtronic Minimed Inc

Inventors

• Shah Rajiv
• Hoss Udo
• Soundararajan Gopikrishnan
• Van Antwerp Nannette M
• Pham Barry

Classifications

• A61B5/14865 Primary

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/6849

  in combination with a needle set · CPC title