Radiomic signature of a perivascular region
US-2024404058-A1 · Dec 5, 2024 · US
US9488741B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9488741-B2 |
| Application number | US-201514687948-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 16, 2015 |
| Priority date | Apr 18, 2014 |
| Publication date | Nov 8, 2016 |
| Grant date | Nov 8, 2016 |
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Provided is an X-ray energy spectrum estimation method capable of reproducing, with high precision, information on an attenuation path to which an X-ray is irradiated, and performing, with high precision, reconstruction of an X-ray CT image by enabling high-precision estimation of spectrum of energy released from an X-ray source device. An energy spectrum estimation device ( 92 ) normalizes a response function, and calculates a modified efficiency matrix from the normalized response function, a detection efficiency matrix, and a measurement-system correction coefficient. The energy spectrum estimation device then calculates a particular result in accordance with a Bayesian estimation equation, without divergence, with use of the calculated modified efficiency matrix, the normalized modified efficiency matrix, and an attenuation characteristic curve obtained by a measurement circuit ( 30 ). The energy spectrum ( 92 ) calculates an X-ray energy spectrum by dividing, by the normalized modified efficiency matrix, the particular result obtained by the Bayesian estimation equation.
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What is claimed is: 1. An X-ray energy spectrum measurement method comprising: causing an X-ray generated from an X-ray source to pass through an attenuation material whose thickness changes stepwise or continuously; moving the attenuation material by use of a movement mechanism for changing the thickness of the attenuation material through which the X-ray generated from the X-ray source passes; detecting the X-ray passed through the attenuation material; calculating an attenuation characteristic curve of the detected X-ray; calculating an X-ray energy spectrum, from the attenuation characteristic curve of the X-ray, in accordance with a Bayesian estimation equation with use of at least a normalized response function and modified efficiency matrix; normalizing the modified efficiency matrix; dividing the calculated X-ray energy spectrum by the normalized modified efficiency matrix; and thereby estimating the X-ray energy spectrum of the X-ray generated by the X-ray source. 2. An X-ray energy spectrum measurement method according to claim 1 , wherein the modified efficiency matrix is calculated by use of the response function, the normalized response function, a detection efficiency matrix, and a measurement-system correction coefficient. 3. An X-ray energy spectrum measurement method according to claim 2 , wherein: the X-ray source generates a fan-beam X-ray; and the X-ray passed through the moving attenuation material is detected by a detector in which a plurality of detectors are arranged in a line. 4. An X-ray energy spectrum measurement apparatus comprising: an X-ray source which generates an X-ray; an attenuation material through which the X-ray generated from the X-ray source passes, the attenuation material changing in thickness stepwise or continuously; a movement mechanism which moves the attenuation material for changing the thickness of the attenuation material through which the X-ray generated from the X-ray source passes; a detector which detects the X-ray passed through the attenuation material; and an X-ray energy computation unit configured to calculate an attenuation characteristic curve of the X-ray detected by the detector, and estimate an X-ray energy spectrum of the X-ray generated by the X-ray source, from the attenuation characteristic curve of the X-ray, in accordance with a Bayesian estimation equation with use of at least a normalized response function and a modified efficiency matrix. 5. An X-ray energy spectrum measurement apparatus according to claim 4 , wherein the X-ray energy computation unit includes: a response function evaluation unit which outputs a response function and a normalized response function; a detection efficiency evaluation unit which outputs a detection efficiency evaluation matrix; a measurement-system correction-coefficient measurement unit which outputs a measurement-system correction coefficient; an energy spectrum estimation unit which estimates an X-ray energy spectrum of the X-ray generated by the X-ray source, from the attenuation characteristic curve of the X-ray, in accordance with the Bayesian estimation equation with use of the response function, the normalized response function, the detection efficiency matrix, and the measurement-system correction coefficient; and an output unit which displays the X-ray energy spectrum estimated by the energy spectrum estimation unit. 6. An X-ray energy spectrum measurement apparatus according to claim 5 , wherein the energy spectrum estimation unit includes: a Bayesian estimation equation computation unit which calculates an energy spectrum, from the attenuation characteristic curve of the X-ray, in accordance with the Bayesian estimation equation; a computing-unit which computes a modified efficiency matrix from the response function, the normalized response function, the detection efficiency matrix, and the measurement-system correction coefficient; and a dividing-unit configured to normalize the modified efficiency matrix, divide, the energy spectrum calculated in accordance with the Bayesian estimation computation unit, by the normalized modified efficiency matrix, and calculate an X-ray energy spectrum of the X-ray generated by the X-ray source. 7. An X-ray energy spectrum measurement apparatus according to claim 5 , wherein: the X-ray source generates a fan-beam X-ray; and the detector includes a plurality of detectors arranged in a line. 8. An X-ray CT apparatus comprising: an X-ray source which generates an X-ray; an attenuation material through which the X-ray generated from the X-ray source passes, the attenuation material changing in thickness stepwise or continuously; a movement mechanism which moves the attenuation material for changing a thickness of the attenuation material through which the X-ray generated from the X-ray source passes; a detector which detects the X-ray passed through the attenuation material; an X-ray energy computation unit configured to calculate an attenuation characteristic curve of an X-ray detected by the detector, and estimate an X-ray energy spectrum of the X-ray generated by the X-ray source, from the attenuation characteristic curve of the X-ray, in accordance with a Bayesian estimation equation with use of at least a response function normalized and a modified efficiency matrix; a memory which stores an energy spectrum of the X-ray generated from the X-ray source, the energy spectrum being computed by the X-ray energy computation unit; a correction computation processing unit configured to compare data of the X-ray obtained by the detector, the X-ray having passed through a specimen, with the X-ray energy spectrum stored in the memory, correct attenuation path information of the specimen, and reconstruct an image of the specimen; and an output unit which displays the specimen image reconstructed by the correction computation processing unit. 9. An X-ray CT apparatus according to claim 8 , wherein the X-ray energy computation unit includes: a response function evaluation unit which outputs a response function and a normalized response function; a detection efficiency evaluation unit which outputs a detection efficiency evaluation matrix; a measurement-system correction-coefficient measurement unit which outputs a measurement-system correction coefficient; an energy spectrum estimation unit which estimates an X-ray energy spectrum of the X-ray generated by the X-ray source, from the attenuation characteristic curve of the X-ray, in accordance with the Bayesian estimation equation with use of the response function, the normalized response function, the detection efficiency matrix, and the measurement-system correction coefficient; and an output unit which displays the X-ray energy spectrum estimated by the energy spectrum estimation unit. 10. An X-ray CT apparatus according to claim 9 , wherein the energy spectrum estimation unit includes: a Bayesian estimation equation computation unit which calculates an energy spectrum, from the attenuation characteristic curve of the X-ray, in accordance with the Bayesian estimation equation; a computing-unit which computes a modified efficiency matrix from the response function, the normalized response function, the detection efficiency matrix, and the measurement correction coefficient; and a dividing-unit configured to normalize the modified efficiency matrix, divide, the energy spectrum calculated in accordance with the Bayesian estimation computation unit, by the normalized modified efficiency matrix, and calculate an X-ray energy spectrum of the X-ray generated by the X-ray source.
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