Acousto-electromagnetic investigation of physical properties of an object

Patent metadata

Field	Value
Publication number	US-9488573-B2
Application number	US-201214346462-A
Country	US
Kind code	B2
Filing date	Sep 19, 2012
Priority date	Sep 23, 2011
Publication date	Nov 8, 2016
Grant date	Nov 8, 2016

Abstract

An imaging system for an object such as human or animal tissue applies acoustic vibrations localized in two or three dimensions and simultaneously illuminates the object with an illuminating electromagnetic wave. The acoustic vibration comprises a carrier wave that is amplitude modulated by an AM waveform. The carrier wave is selected to provide the localization of the acoustic vibration, whereas the AM waveform includes a frequency component selected to provide a vibration of the object of greater magnitude than the carrier wave. To detect a Doppler component shifted by the frequency of said frequency component of the AM waveform, a signal processing apparatus comprises a phase locked-loop locked to the EM frequency, producing a frequency-demodulated signal comprising the set of the Doppler components, and a lock-in amplifier configured to extract a signal at a reference frequency equal to the frequency of a frequency component of the AM waveform.

First claim

The invention claimed is:

1. A method of investigating physical properties of an object, comprising:
applying to the object acoustic vibration localised in two or three dimensions in a region in the object, the acoustic vibration comprising a carrier wave that is amplitude modulated by an AM waveform, the carrier wave being selected to provide the localization of the acoustic vibration and the AM waveform including a frequency component selected to provide a vibration of the object of greater magnitude than the carrier wave;
simultaneously illuminating the object with an illuminating electromagnetic wave that has an EM frequency in a range extending up to 30 THz, the vibration direction of the acoustic vibration having a component parallel to the propagation direction of the illuminating electromagnetic wave so that the acoustic vibration of the object in the region generates a scattered electromagnetic wave including a set of Doppler components shifted from the frequency of the illuminating electromagnetic wave by frequencies of the vibration of the object caused by the acoustic vibration and multiples thereof; and
receiving the scattered electromagnetic wave generated in the region,
detecting, from the received, scattered electromagnetic wave, a Doppler component shifted from the frequency of the illuminating electromagnetic wave by the frequency of said frequency component of the AM waveform; and
outputting a signal representing at least one characteristic of the detected Doppler component.

2. The method according to claim 1 , wherein said AM waveform has a fundamental frequency component, said frequency component of the AM waveform being the fundamental frequency component.

3. The method according to claim 2 , wherein said AM waveform further includes other frequency components.

4. The method according to claim 3 , wherein the AM waveform is a square wave.

5. The method according to claim 1 , wherein said frequency component of the AM waveform has a period of the same order of magnitude as the acoustic relaxation time of the region of the object.

6. The method according to claim 1 , wherein said frequency component of the AM waveform is selected to provide a resonant vibration of the object.

7. The method according to claim 1 , wherein the carrier wave has a frequency in the range from 10 kHz to 1 GHz.

8. The method according to claim 1 , wherein said frequency component of the AM waveform is in the range from 1 Hz to 100 MHz.

9. The method according to claim 8 , wherein said frequency component of the AM waveform is in a range extending up from 10 kHz and/or extending up to 1 kHz.

10. The method according to claim 8 , wherein the illuminating electromagnetic wave has a frequency in a range extending up to 2 GHz.

11. The method according to claim 1 , wherein the illuminating electromagnetic wave has an EM frequency in a range extending up from a value of twice said frequency component of the AM waveform, preferably up from a value of ten times said frequency component of the AM waveform.

12. The method according to claim 1 , wherein said object is a biological object.

13. The method according to claim 12 , wherein said biological object is human or animal tissue.

14. The method according to claim 12 , wherein the carrier wave has a frequency in a range extending up from 1 MHz and/or extending up to 50 MHz.

15. The method according to claim 1 , wherein the step of detecting Doppler components comprises:
supplying the received, scattered electromagnetic wave to a phase-locked loop locked to the EM frequency to produce a frequency-demodulated signal comprising the set of the Doppler components frequency-demodulated from EM frequency; and
supplying the frequency-demodulated signal to a lock-in amplifier configured to extract a signal at a reference frequency equal to the frequency of said frequency component of the AM waveform.

16. The method according to claim 15 , wherein the lock-in amplifier being configured to generate the amplitude and/or phase of the extracted signal, being said at least one characteristic of the detected Doppler component.

17. The method according to claim 1 , further comprising:
applying, simultaneously with said first mentioned acoustic vibration, a second acoustic vibration localised in two or three dimensions in a further region in the object, the second acoustic vibration comprising a carrier wave that is amplitude modulated by a second AM waveform, the carrier wave being selected to provide the localization of the further acoustic vibration and the second AM waveform including a frequency component of a different frequency from the first mentioned waveform of the first acoustic vibration, selected to provide a vibration of the object of greater magnitude than the carrier wave;
detecting, from the received, scattered electromagnetic wave, a second Doppler component shifted from the frequency of the illuminating electromagnetic wave by the frequency of said frequency component of the second AM waveform; and
outputting a signal representing at least one characteristic of the detected second Doppler component.

18. The method according to claim 1 being a method of imaging an object, wherein:
the step of applying acoustic vibration comprises applying the acoustic vibration localised in a plurality of regions either sequentially or simultaneously but with AM waveforms including frequency components of different frequencies in each region;
the step of receiving the scattered electromagnetic wave comprises receiving the scattered electromagnetic wave generated in each of the plurality of regions;
the step of detecting a Doppler component comprises detecting a Doppler component in respect of each region;
the step of outputting a signal comprises outputting a signal representing at least one characteristic of the detected Doppler component in respect of each region; and
the method further comprises storing data representing the at least one characteristic of the detected Doppler component in respect of each region as image data.

19. A system for investigating physical properties of an object, the system comprising:
an acoustic transducer apparatus arranged to apply to the object acoustic vibration localised in two or three dimensions in a region in the object, the acoustic vibration comprising a carrier wave that is amplitude modulated by an AM waveform;
a transmitter arrangement arranged to illuminate the object with an illuminating electromagnetic wave having a frequency in a range extending down from 30 THz simultaneously with the application of acoustic vibration, the vibration direction of the acoustic vibration having a component parallel to the propagation direction of the illuminating electromagnetic wave so that so that the vibration of the object caused by the acoustic vibration in the region generates a scattered electromagnetic wave including a set of Doppler components shifted from the frequency of the illuminating electromagnetic wave by frequencies of the vibration of the object caused by the acoustic vibration and multiples thereof; and
a receiver arrangement arranged to receive the scattered electromagnetic wave generated in the region; and
a signal processing apparatus arranged to detect, from the received, scattered electromagnetic wave, a Doppler component shifted from the frequency of the illuminating electromagnetic wave by the frequency of a frequency component of the AM waveform, and to output a signal representing at least one characteristic of the detected Doppler component.

Assignees

• Isis Innovation

Inventors

• Edwards David John
• Vachirimon Pithawat

Classifications

• G01N21/47 Primary

  Scattering, i.e. diffuse reflection (G01N21/25, G01N21/41 take precedence {G01N21/55 takes precedence}) · CPC title

• G01S13/89

  for mapping or imaging · CPC title

• G01N21/3581

  using far infrared light; using Terahertz radiation · CPC title

• G01S13/50

  Systems of measurement based on relative movement of target · CPC title

• G01N29/0654

  Imaging · CPC title