Inhibition of granulocyte colony stimulating factor in the treatment of cancer
US-2016368980-A1 · Dec 22, 2016 · US
US9487581B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9487581-B2 |
| Application number | US-81789406-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 2, 2006 |
| Priority date | Mar 8, 2005 |
| Publication date | Nov 8, 2016 |
| Grant date | Nov 8, 2016 |
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The present invention provides for novel compositions of anti-CTLA-4 antibodies comprising a chelating agent. Also provided are method of treating diseases and conditions with novel compositions of CTLA-4 antibodies, including various neoplasia conditions.
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What is claimed is: 1. A composition comprising: a chelating agent at a concentration of about 0.01 mM to about 5.0 mM; histidine at a concentration of about 1 mM to about 100 mM; a surfactant at a concentration of about 0.01 mg/ml to about 10 mg/ml; trehalose at a concentration of about 100 mM to about 300 mM; and an antibody at a concentration of about 1 mg/ml to about 200 mg/ml, wherein said antibody binds to human CTLA-4 and comprises the heavy chain CDR1, CDR2, and CD…
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