Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
US-9221812-B2 · Dec 29, 2015 · US
3,4,5-trimethoxystyrylarylaminopropenones as potential anticancer agents
US9487482B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9487482-B2 |
| Application number | US-201514689742-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 17, 2015 |
| Priority date | May 9, 2014 |
| Publication date | Nov 8, 2016 |
| Grant date | Nov 8, 2016 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The present invention relate to compounds of general formula A. The invention also provides the synthesis of 3,4,5-trimethoxystyrylarylaminopropenones useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof. wherein: R=H, OMe, Cl, F, OH, Me X=aryl, heteroaryl.
First claim
Opening claim text (preview).
We claim: 1. A novel 3,4,5-trimethoxystyrylarylaminopropenone of general formulae A wherein: R=H, OMe, Cl, F, OH, Me X=aryl, heteroaryl. 2. A novel 3,4,5-trimethoxystyrylarylaminopropenone of general formulae A as claimed in claim 1 selected from the compounds of 7a-7y, 8a-8y, 9a-9y, 10a-10y, 11a-11y, 12a-12y, 13a-13y, 14a-14y, 15a-15y, 16a-16y, 17a-17y, 18a-18y, 19a-19y, 20a-20y, and 21a-21y, X=aryl, heteroaryl. 3. A novel 3,4,5-trimethoxystyrylarylaminopropenone of general formulae A as claimed in claim 1 selected from the following compounds: (Z)-1-phenyl-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7a) (Z)-1-(4-methoxyphenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7b) (Z)-1-(3-methoxyphenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7c) (Z)-1-(2-methoxyphenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7d) (Z)-1-(4-hydroxyphenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7e) (Z)-1-(4-nitrophenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7f) (Z)-1-(4-aminophenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7g) (Z)-1-(2-nitrophenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7h) (Z)-1-(2-aminophenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7i) (Z)-1-(4-fluorophenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7J) (Z)-1-(4-(trifluoromethyl)phenyl)-3-(3-((3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7k) (Z)-1-(3-fluorophenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7l) (Z)-1-(3-chlorophenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7m) (Z)-1-(4-chlorophenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7n) (Z)-1-(4-(trifluoromethoxy)phenyl)-3-(3-((3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7o) (Z)-1-(3,4-dimethoxyphenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7p) (Z)-1-(3-hydroxy-4-methoxyphenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7q) (Z)-1-(3-fluoro-4-methoxyphenyl)-3-(3-((3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7r) (Z)-1-(3-chloro-4-methoxyphenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7s) (Z)-1-(4-methoxy-3-nitrophenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7t) (Z)-1-(3-amino-4-methoxyphenyl)-3-(3-((3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7u) (Z)-1-(1H-indol-3-yl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7v) (Z)-1-(1-methyl-1H-indol-3-yl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7w) (Z)-1-(3,4,5-trimethoxyphenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7x) (Z)-1-(2-bromo-3,4,5-trimethoxyphenyl)-3-(3-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (7y) (Z)-1-phenyl-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8a) (Z)-1-(4-methoxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8b) (Z)-1-(3-methoxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8c) (Z)-1-(2-methoxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8d) (Z)-1-(4-hydroxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8e) (Z)-1-(4-nitrophenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8f) (Z)-1-(4-aminophenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8g) (Z)-1-(2-nitrophenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8h) (Z)-1-(2-aminophenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8i) (Z)-1-(4-fluorophenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8j) (Z)-1-(4-(trifluoromethyl)phenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8k) (Z)-1-(3-fluorophenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8l) (Z)-1-(3-chlorophenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8m) (Z)-1-(4-chlorophenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8n) (Z)-1-(4-(trifluoromethoxy)phenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8o) (Z)-1-(3,4-dimethoxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8p) (Z)-1-(3-hydroxy-4-methoxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8q) (Z)-1-(3-fluoro-4-methoxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8r) (Z)-1-(3-chloro-4-methoxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8s) (Z)-1-(4-methoxy-3-nitrophenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8t) (Z)-1-(3-amino-4-methoxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8u) (Z)-1-(1H-indol-3-yl)-3-(4-((3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (8v) (Z)-1-(1-methyl-1H-indol-3-yl)-3-(4-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (8w) (Z)-1-(3,4,5-trimethoxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8x) (Z)-1-(2-bromo-3,4,5-trimethoxyphenyl)-3-((4-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (8y) (Z)-1-phenyl-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9a) (Z)-1-(4-methoxyphenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9b) (Z)-1-(3-methoxyphenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9c) (Z)-1-(2-methoxyphenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9d) (Z)-1-(4-hydroxyphenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9e) (Z)-1-(4-nitrophenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9f) (Z)-1-(4-aminophenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9g) (Z)-1-(2-nitrophenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9h) (Z)-1-(2-aminophenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9i) (Z)-1-(4-fluorophenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9j) (Z)-1-(4-(trifluoromethyl)phenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9k) (Z)-1-(3-fluorophenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9l) (Z)-1-(3-chlorophenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9m) (Z)-1-(4-chlorophenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9n) (Z)-1-(4-(trifluoromethoxy)phenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9o) (Z)-1-(3,4-dimethoxyphenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9p) (Z)-1-(3-hydroxy-4-methoxyphenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9q) (Z)-1-(3-fluoro-4-methoxyphenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9r) (Z)-1-(3-chloro-4-methoxyphenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9s) (Z)-1-(4-methoxy-3-nitrophenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9t) (Z)-1-(3-amino-4-methoxyphenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (9u) (Z)-1-(1H-indol-3-yl)-3-(2-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (9v) (Z)-1-(1-methyl-1H-indol-3-yl)-3-(2-(3,4,5-trimethoxystyryl)phenylamino)prop-2-en-1-one (9w) (Z)-1-(3,4,5-trimethoxyphenyl)-3-((2-((Z)-3,4,5-trimethoxystyryl)phenyl)ami
Assignees
Inventors
Classifications
Antineoplastic agents · CPC title
with an alkyl or cycloalkyl radical attached to the ring nitrogen atom · CPC title
Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton · CPC title
having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton · CPC title
and containing six-membered aromatic rings · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9487482B2 cover?
- The present invention relate to compounds of general formula A. The invention also provides the synthesis of 3,4,5-trimethoxystyrylarylaminopropenones useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof. wherein:…
- Who is the assignee on this patent?
- Council Scient Ind Res
- What technology area does this patent fall under?
- Primary CPC classification C07D209/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 08 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).