Radiation therapy device for ocular melanoma

Patent metadata

Field	Value
Publication number	US-9486645-B2
Application number	US-201414563256-A
Country	US
Kind code	B2
Filing date	Dec 8, 2014
Priority date	Dec 9, 2013
Publication date	Nov 8, 2016
Grant date	Nov 8, 2016

Abstract

The present invention advantageously provides a method and system for providing accurately localized, non-invasive radiation treatment for ocular melanoma or other intraocular indications through the completion of specified research tasks. The present invention further provides for dynamic localization of tumors associated with such indications. The system of the present invention includes the CYBERKNIFE system, a robust eye pupil tracking system, and an integrated software package to achieve intra-beam fractional tumor tracking during radiation delivery. The system may further include a mechanical phantom incorporated with a radiation dosimetry calibration kit for validation.

First claim

What is claimed is:

1. A system for non-invasively treating ocular melanoma, the system comprising:
a CT imaging system, the CT imaging system generating a series of 3D images of a patient's eye and a tumor within the eye;
an optical imaging system, the optical imaging system generating a series of 2D images of a pupil of the patient's eye;
a processor in communication with the CT imaging system and the optical imaging system programmed to correlate the pupil's 2D images with the tumor's 3D images to determine a location of the tumor relative to the pupil in each of a plurality of pupil locations; and
a robotic arm in communication with the processor and configured to direct radiation beams toward the tumor, the direction of the beams being based at least in part on the correlations by the processor.

2. The system of claim 1 , wherein the correlation between the pupil's 2D images and the tumor's 3D images is performed by the processor according to the equation:
T i ( S )= A ( P i ( Se )) T 0 ( S )
where:
T i (S) is the tumor's position within the patient's skull coordinate system;
T 0 (S) is an initial position of the tumor within the patient's skull coordinate system;
P i (Se) is the pupil's position within the patient's eye coordinate system;
A is a transformation that is a function of P i (Se).

3. The system of claim 2 , wherein the initial position of the tumor is the position of the tumor when the eye is in a neutral position.

4. The system of claim 2 , wherein the transformation A is an affine transformation.

5. The system of claim 4 , wherein the affine transformation is a 3×4 affine transformation.

6. The system of claim 1 , further comprising an x-ray imaging system.

7. The system of claim 6 , wherein a new location of the tumor relative to the pupil when the eye moves is determined by the processor according to the equation:

T
updated

=

⁢

T
current

⁡

(
S
)

×

T

HeadCT
⁢

⁢
2
⁢

-

⁢
To
⁢

-

⁢
HeadCT
⁢

⁢
1

×

T

HeadXSI
⁢

-

⁢
To
⁢

-

⁢
HeadCT
⁢

⁢
1

-
1

=

⁢

A
⁡

(

P
current

⁡

(
Se
)

)

⁢

T
0

⁡

(
S
)

×

T

HeadCT
⁢

⁢
2
⁢

-

⁢
To
⁢

-

⁢
HeadCT
⁢

⁢
1

×

T

HeadXSI
⁢

-

⁢
To
⁢

-

⁢
HeadCT
⁢

⁢
1

-
1

where:
T updated is the tumor's new position of the tumor relative to the pupil;
T current (S) is tumor's new position within the patient's skull coordinate system;
T HeadCT2-To-HeadCT1 is a transformation based on a change in position of the patient's head between a second series of 3D images by the CT system and a first series of 3D images by the CT system;
T HeadXSI-To-HeadCT1 is a transformation based on a change in position of the patient's head between a position in an x-ray image of the patient's head by th

Assignees

• Univ Miami

Inventors

• Wu Xiaodong
• Zhao Weizhao

Classifications

• A61B6/032

  Transmission computed tomography [CT] · CPC title

• A61N5/1067

  in real time, i.e. during treatment · CPC title

• A61N5/1084

  for delivering multiple intersecting beams at the same time, e.g. gamma knives · CPC title

• A61N5/1017 Primary

  Treatment of the eye, e.g. for "macular degeneration" · CPC title

• A61N2005/1059

  using cameras imaging the patient · CPC title