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US9486429B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9486429-B2 |
| Application number | US-78537404-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 24, 2004 |
| Priority date | Jun 1, 1999 |
| Publication date | Nov 8, 2016 |
| Grant date | Nov 8, 2016 |
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Abstract
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Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of treating pulmonary hypertension comprising administering an amount of citrulline effective to treat pulmonary hypertension in a subject suffering from pulmonary hypertension, wherein said citrulline is administered intravenously. 2. The method of claim 1 , wherein the subject is human. 3. The method of claim 2 , wherein the human is an infant. 4. The method of claim 3 , wherein the pulmonary hypertension is persistent pulmonary hypertension. 5. The method of claim 1 , wherein the citrulline is administered in a dose ranging from about 100 mg to about 30,000 mg. 6. The method of claim 5 , wherein the citrulline is administered in a dose ranging from about 250 mg to about 10,000 mg. 7. The method of claim 5 , wherein the citrulline is administered in a dose ranging from about 200 mg/kg to about 800 mg/kg.
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Classifications
Drugs for disorders of the cardiovascular system · CPC title
Immunosuppressants, e.g. drugs for graft rejection · CPC title
Drugs for immunological or allergic disorders · CPC title
Antihypertensives · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
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- What does patent US9486429B2 cover?
- Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carba…
- Who is the assignee on this patent?
- Summar Marshall L, Christman Brian W, Barr Frederick E, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/198. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 08 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).