Anti-FAP antibodies and methods of use
US-9011847-B2 · Apr 21, 2015 · US
DR5—FAP bispecific death receptor agonistic antibodies
US9481730B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9481730-B2 |
| Application number | US-201013498390-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 27, 2010 |
| Priority date | Sep 29, 2009 |
| Publication date | Nov 1, 2016 |
| Grant date | Nov 1, 2016 |
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- Title
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Abstract
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The present invention relates to bispecific antibodies comprising a first antigen binding site specific for a death receptor and a second antigen binding site specific for a second antigen, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
First claim
Opening claim text (preview).
What is claimed is: 1. A dimeric bispecific antibody comprising a first antibody specific for death receptor 5 polypeptide (DR5) and a second antibody specific for fibroblast activation protein (FAP) wherein the dimeric bispecific antibody is bivalent for DR5, wherein the bispecific antibody comprises a variant Fc region having a reduced affinity to Fcγ receptors compared to a wildtype Fc region, and further wherein the bispecific antibody induces apoptosis by cross-linking DR5. 2. The dimeric bispecific antibody of claim 1 , wherein the first antibody is an Immunoglobulin (Ig) molecule comprising a light chain and a heavy chain and the second antibody is selected from the group consisting of scFv, scFab, Fab or Fv. 3. The dimeric bispecific antibody of claim 2 , wherein the second antibody is fused to the N- or C-terminus of the heavy chain of the Ig molecule. 4. The dimeric bispecific antibody of claim 2 , wherein the second antibody is fused to the N- or C-terminus of the light chain of the Ig molecule. 5. The dimeric bispecific antibody of claim 2 , wherein the Ig molecule is a IgG. 6. The dimeric bispecific antibody of claim 2 , wherein the second antibody is fused to the Ig molecule by a peptide linker. 7. The dimeric bispecific antibody of claim 6 , wherein the peptide linker has a length of about 10-30 amino acids. 8. The dimeric bispecific antibody of claim 2 , wherein the second antibody comprises additional cysteine residues to form disulfide bonds. 9. A pharmaceutical composition comprising the dimeric bispecific antibody of claim 1 and a pharmaceutical carrier.
Assignees
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Classifications
Antineoplastic agents · CPC title
for joint disorders, e.g. arthritis, arthrosis · CPC title
from tumour cells · CPC title
Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation · CPC title
Carcino-embryonic Antigens · CPC title
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Frequently asked questions
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- What does patent US9481730B2 cover?
- The present invention relates to bispecific antibodies comprising a first antigen binding site specific for a death receptor and a second antigen binding site specific for a second antigen, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
- Who is the assignee on this patent?
- Bruenker Peter, Ferrara Koller Claudia, Grau Sandra, and 6 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/2878. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).