Modular radiochemistry synthesis system

Patent metadata

Field	Value
Publication number	US-9481705-B2
Application number	US-201514941164-A
Country	US
Kind code	B2
Filing date	Nov 13, 2015
Priority date	Aug 19, 2008
Publication date	Nov 1, 2016
Grant date	Nov 1, 2016

Abstract

A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

First claim

We claim:

1. A method of performing radiochemistry synthesis comprising:
providing a vial having an upper rim, the vial configured to hold one or more reactants or reactant products of the radiochemistry synthesis;
providing a reactor vessel having a heating element and a thermally-conductive heat transfer block, the vial being contained within the thermally-conductive heat transfer block;
providing a stationary fluidic interface disposed above the reactor vessel and vial and comprising a plurality of elastomeric stoppers, wherein at least one of the elastomeric stoppers comprises a completely sealed surface and at least one of the elastomeric stoppers comprises a port fluidically coupled to tubing;
providing a horizontal actuator coupled to the reactor vessel and configured to move the reactor vessel along a substantially horizontal axis of motion;
providing a vertical actuator coupled to the reactor vessel and configured to move the reactor vessel along a substantially vertical axis of motion;
providing a motion controller operatively coupled to the horizontal actuator and the vertical actuator; and
wherein the motion controller operates in accordance with a program to selectively seal the upper rim of the vial against the plurality of elastomeric stoppers.

2. The method of claim 1 , wherein the program is preprogrammed using a control unit associated with a computer.

3. The method of claim 1 , wherein the tubing is connected to a purification unit and contents of the vial are transferred from the vial to the purification unit.

4. The method of claim 3 , wherein a dip tube extends from the stationary fluidic interface and into the vial when the upper rim of the vial is sealed against the plurality of elastomeric stoppers.

5. The method of claim 1 , wherein the tubing is connected to a source of vacuum and the source of vacuum transfers contents out of the vial.

6. The method of claim 1 , wherein the tubing is connected to a source of inert gas, wherein the source of inert gas is introduced into the vial.

7. The method of claim 1 , wherein the tubing is connected to one or more reagent sources, wherein at least one reagent is introduced into the vial.

8. The method of claim 1 , further comprising measuring the radioactivity of the reactant products of the radiochemistry synthesis with a radiation sensor.

9. The method of claim 1 , wherein the stationary fluidic interface comprises a first elastomeric stopper in a first position that includes a conduit that extends through the first elastomeric stopper and second elastomeric stopper in a second position that comprises the completely sealed surface.

10. The method of claim 9 , wherein the second elastomeric stopper comprises a chemically inert gasket.

11. The method of claim 1 , wherein the stationary fluidic interface comprises a first elastomeric stopper in a first position that includes tubing that extends through the first elastomeric stopper, a second elastomeric stopper in a second position that comprises the completely sealed surface, and third elastomeric stopper that includes a dip tube that extends through the third elastomeric stopper.

12. The method of claim 11 , further comprising sealing the upper rim of the vial against the first elastomeric stopper and adding reagents into the vial.

13. The method of claim 12 , wherein the reagents comprise an aqueous F-18 solution, a dry organic solvent, a phase transfer agent, and a carbonate.

14. The method of claim 12 , further comprising mixing the contents of the vial by bubbling an inert gas in the vial.

15. The method of claim 11 , further comprising sealing the upper rim of the vial against the second elastomeric stopper and heating the contents of the vial.

16. The method of claim 11 , further comprising sealing the upper rim of the vial against the third elastomeric stopper and transferring the contents of the vial out of the vial.

Assignees

• Univ California

Inventors

• Satyamurthy Nagichettiar
• Barrio Jorge R
• Amarasekera Bernard
• Van Dam R Michael
• Olma Sebastian
• Williams Dirk
• Eddings Mark
• Shen Clifton Kwang-Fu

Classifications

• B01J2219/24

  Stationary reactors without moving elements inside · CPC title

• C07C201/06

  Preparation of nitro compounds · CPC title

• C07H19/16 Primary

  Purine radicals · CPC title

• B01J19/126 Primary

  Microwaves · CPC title

• C07B59/001

  Acyclic or carbocyclic compounds · CPC title