Glyconjugate Vaccines
US-2024382585-A1 · Nov 21, 2024 · US
Multivalent pneumococcal polysaccharide-protein conjugate composition
US9480736B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9480736-B2 |
| Application number | US-201414520108-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 21, 2014 |
| Priority date | Apr 8, 2005 |
| Publication date | Nov 1, 2016 |
| Grant date | Nov 1, 2016 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 1 polysaccharide covalently linked to a carrier protein, the method including partial de-O-acetylation of the polysaccharide by mild hydrolysis in an alkaline pH buffer.
First claim
Opening claim text (preview).
What is claimed is: 1. A purified Streptococcus pneumoniae serotype 1 polysaccharide that is de-O-acetylated to approximately 40 mole percent, wherein said polysaccharide is conjugated to a carrier protein. 2. The purified Streptococcus pneumoniae serotype 1 polysaccharide of claim 1 , wherein said polysaccharide is obtained by reacting purified Streptococcus pneumoniae serotype 1 polysaccharide with an alkaline pH buffer. 3. The purified Streptococcus pneumoniae serotype 1 polysaccharide of claim 2 , wherein said alkaline pH buffer is a sodium bicarbonate/carbonate buffer at pH 9.0. 4. The purified Streptococcus pneumoniae serotype 1 polysaccharide of claim 3 , wherein said buffer concentration is 30 mM.
Assignees
Inventors
Classifications
Antibacterial agents · CPC title
Immunostimulants · CPC title
Drugs for disorders of the respiratory system · CPC title
Haptens or antigens, bound to carriers · CPC title
- A61K39/092Primary
Streptococcus · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9480736B2 cover?
- An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, i…
- Who is the assignee on this patent?
- Wyeth Llc
- What technology area does this patent fall under?
- Primary CPC classification A61K39/092. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).