Compositions and methods to prevent cancer with cupredoxins
US-2015374780-A1 · Dec 31, 2015 · US
Compositions and methods
US9480735B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9480735-B2 |
| Application number | US-201414283727-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 21, 2014 |
| Priority date | Jul 25, 2008 |
| Publication date | Nov 1, 2016 |
| Grant date | Nov 1, 2016 |
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- Title
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Abstract
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The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; of (iii) an immunogenic fragment of an Rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
First claim
Opening claim text (preview).
We claim: 1. A sterile pharmaceutical composition comprising a polypeptide which comprises: (i) an Rv2386c protein comprising an amino acid sequence selected from the group consisting of SEQ ID NOS: 1 and 6; or (ii) an Rv2386c protein comprising an amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NOS: 1 and 6; and a pharmaceutically acceptable carrier or excipient. 2. An immunogenic composition comprising a polypeptide which comprises: (i) an Rv2386c protein comprising an amino acid sequence selected from the group consisting of SEQ ID NOS: 1 and 6; or (ii) an Rv2386c protein comprising an amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NOS: 1 and 6; and a non-specific immune response enhancer. 3. The composition according to claim 1 , wherein the polypeptide comprises an amino acid sequence at least 90% identical to SEQ ID NO: 1. 4. The immunogenic composition according to claim 2 , wherein the polypeptide comprises an amino acid sequence at least 90% identical to SEQ ID NO:1. 5. The composition according to claim 1 , wherein the polypeptide comprises an amino acid sequence at least 90% identical to SEQ ID NO: 6. 6. The immunogenic composition according to claim 2 , wherein the polypeptide comprises an amino acid sequence at least 90% identical to SEQ ID NO:6.
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- What does patent US9480735B2 cover?
- The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; of (iii) an immunogenic fragment of an Rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
- Who is the assignee on this patent?
- Glaxosmithkline Biologicals Sa, Glaxo Group Ltd, Glaxosmithkline Biologicals Sa
- What technology area does this patent fall under?
- Primary CPC classification C07K14/35. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).