Methods and systems for treatment of inflammatory diseases with nitric oxide
US-9198853-B2 · Dec 1, 2015 · US
US9480708B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9480708-B2 |
| Application number | US-201514924613-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 27, 2015 |
| Priority date | Sep 19, 2012 |
| Publication date | Nov 1, 2016 |
| Grant date | Nov 1, 2016 |
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The present invention generally relates to compositions and methods for transdermal drug delivery, including treatment and prevention of learning and memory disorders, and enhancement of learning or memory. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
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What is claimed is: 1. A method, comprising: administering, to the skin of a subject to enhance learning and/or memory in the subject, a composition that is a cream, gel, lotion, or ointment, wherein the composition is stable at room temperature and comprises molecular nitric oxide and phosphatidylcholine wherein the molecular nitric oxide is present within the composition as a gas or bound by hydrogen bonds or van der Waals forces to the phosphatidylcholine.…
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