Treatment of skin and soft tissue infection with nitric oxide

Patent metadata

Field	Value
Publication number	US-9480705-B2
Application number	US-201514924564-A
Country	US
Kind code	B2
Filing date	Oct 27, 2015
Priority date	Sep 19, 2012
Publication date	Nov 1, 2016
Grant date	Nov 1, 2016

Abstract

The present invention generally relates to compositions and methods for treatment of skin and/or other soft tissues that are infected with bacteria such as Staphylococcus aureus , and/or other infectious organisms. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a site of infection, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

First claim

What is claimed is:

1. A method, comprising:
administering, to the skin of a subject having or at risk of infection, a composition that is a cream, gel, lotion, or ointment, wherein the composition is stable at room temperature and comprises molecular nitric oxide and phosphatidylcholine wherein the molecular nitric oxide is present within the composition as a gas or bound by hydrogen bonds or van der Waals forces to the phosphatidylcholine.

2. The method of…

Assignees

• Transdermal Biotechnology Inc

Inventors

• Perricone Nicholas V

Classifications

• A61P31/00

  Human Necessities · mapped topic

• A61K9/0014

  Human Necessities · mapped topic

• A61K9/10

  Human Necessities · mapped topic

• A61P17/10

  Human Necessities · mapped topic

• A61K47/544

  Human Necessities · mapped topic