Pheromone composition to stimulate reproduction in female suids and methods of use

Patent metadata

Field	Value
Publication number	US-9480689-B1
Application number	US-201514943607-A
Country	US
Kind code	B1
Filing date	Nov 17, 2015
Priority date	Nov 17, 2015
Publication date	Nov 1, 2016
Grant date	Nov 1, 2016

Abstract

The present disclosure provides for compositions and methods of stimulating reproductive behavior and reproductive success and productivity in a suid, such as pigs. The composition may comprise at least one steroid hormone and a heterocyclic aromatic compound. The method comprises administering the pheromone composition to the suid for a period of time.

First claim

What is claimed is:

1. A composition for stimulating reproductive behavior and increasing reproductive success and productivity in a female suid, the composition comprising a combination of pheromonal agents, wherein the pheromonal agents comprise at least one steroid hormone and quinoline.

2. The composition of claim 1 , wherein the steroid hormone is an androgen steroid selected from the group consisting of androstenone, androstenol, androstadienone, estratetraenol, and combinations thereof.

3. The composition of claim 2 , wherein the androgen steroid consists of androstenone and androstenol.

4. The composition of claim 2 , wherein the androgen steroid is present in an amount from between about 0.0001% to about 1% (w/w) of the composition.

5. The composition of claim 1 , wherein quinoline is present in an amount from between about 0.0001% to about 1% (w/w) of the composition.

6. The composition of claim 1 , wherein the composition further comprises a carrier solvent.

7. The composition of claim 6 , wherein the carrier solvent is selected from the group consisting of lipophilic organic diluents, alcohols, ethylene glycol, propylene glycol, dipropylene glycol, ether, chloroform, benzene, carbon disulfide, oils including non-volatile and volatile liquids and oils, water, and combinations thereof.

8. The composition of claim 7 , wherein the alcohol is selected from the group consisting of ethanol, propanol, isopropanol, butanol, pentanol, hexanol, heptanol, octanol, phenyl ethyl alcohol, and combinations thereof.

9. The composition of claim 1 , wherein the composition further comprises an additional component selected from the group consisting of a surfactant, a thickener, a propellant, a fragrance, and combinations thereof.

10. A method of stimulating reproductive behavior and increasing reproductive success and productivity in a female suid comprising: administering a pheromone composition to the suid, the composition comprising a combination of pheromonal agents, wherein the pheromonal agents comprise at least one steroid hormone and quinoline, and wherein the amount of pheromonal agents administered to the animal is between about 1.0 ng/mL to about 1.0 g/mL.

11. The method of claim 10 , wherein the suid is a sow.

12. The method of claim 10 , wherein the method of administration is inhalation administration.

13. The method of claim 10 , wherein the composition is formulated as a spray.

14. The method of claim 10 , wherein administering the spray composition comprises spraying the suid or spraying the suid's environment with the composition.

15. A method of stimulating reproductive behavior and increasing reproductive success and productivity in a suid comprising: administering an effective amount of a pheromone spray composition to the suid, the spray composition comprising about 0.0004% (w/w) androstenone, about 0.0004% (w/w) androstenol, about 0.0004% (w/w) quinoline, about 5% (w/w) isopropanol, and about 91% (w/w) water.

16. The method of claim 15 , wherein the suid is a sow.

Assignees

• Univ Texas Tech System
• Animal Biotech Llc

Inventors

• Mcglone John J

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P15/08

  for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis · CPC title

• A23D7/011

  Compositions other than spreads · CPC title

• A61K31/568 Primary

  substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone · CPC title

• A61K31/47

  Quinolines; Isoquinolines · CPC title