Blood flow promoting agent

Patent metadata

Field	Value
Publication number	US-9480668-B2
Application number	US-201314440260-A
Country	US
Kind code	B2
Filing date	Nov 5, 2013
Priority date	Nov 5, 2012
Publication date	Nov 1, 2016
Grant date	Nov 1, 2016

Abstract

The present invention provides a blood flow promoting agent containing citrulline or a salt thereof and capsaicin or capsaicinoids as active ingredients, which is safe even by long-term administration, a food with health claims and a functional food affording such action, particularly, a blood flow promoting agent exhibiting an effective vasodilatory action of capsaicin at a low dose free of irritant property, which can be applied to improvement of athletic performance exhibited in relation to peripheral vasodilatation, suppression of fat accumulation, improvement of skin quality, as well as securing blood circulation in ischemic disease and the like, relaxation of blood vessel biased to coarctation due to advancing age, lifestyle-related diseases and the like, prophylaxis of arteriosclerosis, and prophylaxis of stiff neck, feeling of cold, erectile dysfunction, thrombosis and the like due to blood flow disorder.

First claim

The invention claimed is:

1. A blood flow promoting agent comprising citrulline or a salt thereof and capsaicin or capsaicinoids as active ingredients.

2. The blood flow promoting agent according to claim 1 , wherein the amount of capsaicin or capsaicinoids is 0.1 mg - 20 mg per dose for an adult.

3. The blood flow promoting agent according to claim 1 , wherein the amount of citrulline or a salt thereof is 20 mg - 2000 mg per dose for an adult.

4. The blood flow promoting agent according to claim 1 , wherein citrulline or a salt thereof is contained in a proportion of 10 - 200 parts by weight per 1 part by weight of capsaicin or capsaicinoids.

5. The blood flow promoting agent according to claim 4 , which is in a unit package form for one meal, wherein the unit contains, as an ingestion amount for one time, 20 mg - 2000 mg of citrulline or a salt thereof, and 0.1 mg - 20 mg of capsaicin or capsaicinoids.

6. A method of promoting blood flow, comprising a step of administering citrulline or a salt thereof and capsaicin or capsaicinoids to a subject in need thereof.

7. The method according to claim 6 , wherein the capsaicin or capsaicinoids is administered to the subject in an amount of 0.1 mg - 20 mg per dose for an adult.

8. The method according to claim 6 , wherein the citrulline or a salt thereof is administered to the subject in an amount of 20 mg - 2000 mg per dose for an adult.

9. The method according to claim 6 , wherein the citrulline or a salt thereof is administered to the subject in a proportion of 10 - 200 parts by weight per 1 part by weight of capsaicin or capsaicinoids.

10. The method according to claim 9 , wherein the capsaicin or capsaicinoids is in a unit package form for one meal,
wherein the unit contains, as an ingestion amount for one time, 20 mg - 2000 mg of citrulline or a salt thereof, and 0.1 mg - 20 mg of capsaicin or capsaicinoids.

11. The method according to claim 6 , wherein the method provides for improvement of athletic performance exhibited in relation to peripheral vasodilatation, and wherein the improvement is relative to athletic performance in the absence of administering the blood flow promoting agent to the subject.

Assignees

• Kyowa Hakko Bio Co Ltd

Inventors

• Morita Masahiko
• Kamimura Ayako
• Kobayashi Yoshinori

Classifications

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P9/08

  Vasodilators for multiple indications · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title