Implantable device for drug delivery operated by magnetic force

Patent metadata

Field	Value
Publication number	US-9474853-B2
Application number	US-201414303441-A
Country	US
Kind code	B2
Filing date	Jun 12, 2014
Priority date	Jun 17, 2013
Publication date	Oct 25, 2016
Grant date	Oct 25, 2016

Abstract

Disclosed is an implantable device for drug delivery operated by a magnetic force. The device is provided with a body member and an external magnetic controller which is able to move some of the parts in the body member so that the drug inside the body member can be delivered to a site of interest of the animal body without the extra power source.

First claim

What is claimed is:

1. A device for drug delivery using a magnetic force, the device comprising:
a chamber comprising a top end and a bottom end;
the chamber further comprising at least one septum for charging a drug into the device and at least one outlet for discharging a drug from the device, each being formed on a top end and a bottom end of the chamber, respectively;
an actuator located inside the chamber,
the actuator comprising a cylinder and a piston;
the cylinder comprising at least one inlets formed on a side thereof and a first flange protruding outwardly from an outer surface of the cylinder;
the first flange formed on an end of the cylinder that is closer to the top end of the chamber and configured to abut an inner surface of the chamber;
the piston located inside the cylinder and comprising an end cap;
the end cap covering an end of the piston that is closer to the top end of the chamber such that the end cap is interposed between the first flange and the top end of the chamber and configured to abut the inner surface of the chamber;
a drug reservoir formed in a space within the chamber that is not occupied by the actuator; and
an external controller for supplying an initiating magnetic force to the device, wherein at least one of the first flange and the end cap is formed of a magnetic material or a material that is responsive to a magnetic force such that they abut to each other when the initiating magnetic force is not applied.

2. The device of claim 1 , wherein an operation of the device is initiated by applying the initiating magnetic force M 3 to the top end of the chamber, thus pulling the piston upward and opening the inlet through which a drug is introduced inside of the cylinder followed by a subsequent release of the drug through the outlet and the drug is delivered to a site of a body where the device is implanted,
wherein the first flange has a magnetic force M 1 and the end cap has a magnetic force M 2 , and the M 1 , M 2 and M 3 meet the following condition for the operation: M 2 −M 3 >M 2 −M 1 for the introduction of the drug inside of the cylinder through the inlet; and M 2 −M 3 <M 2 −M 1 for release of the drug to the site of the body where the device is implanted through the outlet.

3. The device of claim 1 , wherein a ratio of a total area of the outlet to that of the inlet is above 1:1.

4. The device of claim 1 , wherein an amount of a drug released from the drug reservoir per actuation is controlled by a size and/or number of the outlet, a ratio of a total area of the inlet and the outlet, or a volume of the cylinder or a combination thereof.

5. The device of claim 1 , wherein the external controller has a magnetic force that meets the following condition: M 2 −M 3 >M 2 −M 1 for the introduction of a drug inside of the cylinder through the inlet; and M 2 −M 3 <M 2 −M 1 for release of the drug through the outlet into a site of a body where the device is implanted, wherein M 1 , M 2 and M 3 are as defined in claim 2 .

6. The device of claim 1 , wherein a number of the outlet formed is between 1 and 30.

7. A method of delivering a drug to a subject, comprising: providing the device of claim 1 , implementing the device at a site of interest of a subject and actuating the device to deliver the drug in an amount sufficient to treat a disease of interest or relieve a symptom of interest.

Assignees

• Snu R&Db Foundation

Inventors

• Choy Young Bin
• Lee Seung Ho

Classifications

• A61M2205/8287

  operated by an external magnetic or electromagnetic field · CPC title

• A61M5/1452 Primary

  pressurised by means of pistons · CPC title

• A61M5/14276

  specially adapted for implantation · CPC title

• A61M2005/14506

  mechanically driven, e.g. spring or clockwork · CPC title

• A61M31/00 Primary

  Devices for introducing or retaining media, e.g. remedies, in cavities of the body (A61M25/00 takes precedence {; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008}) · CPC title