Organic reactions
US-2017253580-A1 · Sep 7, 2017 · US
US9469610B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9469610-B2 |
| Application number | US-201013255970-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 15, 2010 |
| Priority date | Mar 13, 2009 |
| Publication date | Oct 18, 2016 |
| Grant date | Oct 18, 2016 |
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Novel methods for the production of enantiomerically pure (EP) β-lactams by decomposition of α-diazo-β-ketoamides.
Opening claim text (preview).
The invention claimed is: 1. A composition comprising an enantiomerically pure β-lactam having an N-Tr moiety, wherein the nitrogen of said N-Tr moiety is covalently bonded to two of the carbons of the four-atom ring structure wherein the enantiomerically pure β-lactam consists essentially of one of the following: 2. A composition comprising an enantiomerically pure β-lactam wherein the enantiomerically pure β-lactam consists of compound 34 as shown below: 3. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 10. 4. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 11. 5. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 15. 6. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 16. 7. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 17. 8. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 23. 9. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 26. 10. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 27. 11. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 28. 12. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 29. 13. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 30. 14. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 31. 15. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 32. 16. The composition of claim 1 wherein the enantiomerically pure β-lactam consists essentially of Compound 34.
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title
with one oxygen atom directly attached in position 2, e.g. beta-lactams · CPC title
having the nitrogen atom of at least one of the carboxamide groups further acylated · CPC title
having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides · CPC title
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title
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