Automatic system for synthesizing 123I-MIBG and automatic device for synthesizing and dispensing 123I-MIBG comprising the same
US-9221029-B2 · Dec 29, 2015 · US
Labeled molecular imaging agents and methods of use
US9468692B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9468692-B2 |
| Application number | US-201414161809-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 23, 2014 |
| Priority date | Jan 23, 2014 |
| Publication date | Oct 18, 2016 |
| Grant date | Oct 18, 2016 |
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- Title
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Abstract
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Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.
First claim
Opening claim text (preview).
The invention claimed is: 1. An imaging agent comprising a compound of Formula I wherein R is H or C 1 -C 5 alkyl; Y is acyl or sulfonyl; A=null, —O—CH 2 —, —C 2 H 4 —, or —CH 2 —O— Ar=4-substituted phenyl, a 4-substituted naphthalene-1-yl, a 5-substituted naphthalene-1-yl, or a 6-substituted naphthalene-1-yl; X is 18 F, 3 H, —(CH 2 ) m Z, or —O—(CH 2 ) m Z, Z is 18 F or 3 H; n is an integer between 1 and 3; and m is an integer between 1 and 5. 2. The agent of claim 1 wherein Y is acyl. 3. The agent of claim 2 wherein Z is 18 F or 3 H. 4. The agent of claim 3 wherein Z is a singularly occurring 18 F. 5. The agent of claim 1 wherein Formula I is 6. The agent of claim 1 wherein Formula I is 7. The agent of claim 1 wherein Formula I is 8. The agent of claim 1 wherein Formula I is
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Classifications
having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton · CPC title
of an acyclic saturated carbon skeleton · CPC title
Acyclic or carbocyclic compounds · CPC title
having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups · CPC title
- A61K51/0406Primary
Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines · CPC title
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Frequently asked questions
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- What does patent US9468692B2 cover?
- Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.
- Who is the assignee on this patent?
- Gen Electric
- What technology area does this patent fall under?
- Primary CPC classification A61K51/0406. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 18 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).