Noble metal nanoparticles, method for preparing the same and their application

Patent metadata

Field	Value
Publication number	US-9463510-B2
Application number	US-201414485821-A
Country	US
Kind code	B2
Filing date	Sep 15, 2014
Priority date	Nov 27, 2013
Publication date	Oct 11, 2016
Grant date	Oct 11, 2016

Abstract

The present invention discloses a method for preparing noble metal nanoparticles, comprising the following steps: a) preparing an Olea Europaea fruit extract; b) preparing an Acacia Nilotica extract; c) mixing the Olea Europaea fruit extract and the Acacia Nilotica extract for preparing a mixed extract; d) providing an aqueous solution containing a noble metal compound dissolved therein; e) mixing the mixed extract obtained in step c) and the aqueous solution of step d) to form noble metal nanoparticles; noble metal nanoparticles obtained thereby and their use.

First claim

The invention claimed is:

1. Method for preparing noble metal nanoparticles, comprising the following steps:
a) preparing an Olea Europaea fruit extract
b) preparing an Acacia Nilotica extract
c) mixing the Olea Europaea fruit extract and the Acacia Nilotica extract for preparing a mixed extract
d) providing an aqueous solution containing a noble metal compound dissolved therein
e) mixing the mixed extract obtained in step c) and the aqueous solution of step
d) to form noble metal nanoparticles.

2. Method according to claim 1 , wherein the mixed extract obtained in step c) contains flavonoids, phenols and/or pentacyclic triterpenoids.

3. Method according to claim 1 , wherein the preparation of the Olea Europaea fruit extract is performed by adding deionized or distilled water to Olea Europaea fruit.

4. Method according to claim 1 , wherein the preparation of the Acacia Nilotica extract is performed by adding deionized or distilled water to Acacia Nilotica.

5. Method according to claim 1 , wherein the Olea Europaea fruit extract and the Acacia Nilotica extract are mixed in a range of mixing ratios from 5:1to 1:5.

6. Method according to claim 1 , wherein the mixing of step e) is at room temperature.

7. Method according to claim 1 , wherein the noble metal is Au or Ag.

8. Method according to claim 7 , wherein the noble metal compound is chloroauric acid.

9. Method according to claim 1 , wherein the aqueous solution provided in step d) also comprises a surfactant.

10. Noble metal nanoparticles prepared by the method of claim 1 , wherein the average particle size is within a range of 10-100 nm.

11. Noble metal nanoparticles according to claim 10 , wherein the noble metal nanoparticles are substantially spherical.

12. Noble metal nanoparticles according to claim 10 , wherein the noble metal nanoparticles are substantially monodispersed.

13. Noble metal nanoparticles according to claim 10 , wherein the nanoparticles are colloidal.

14. A method of antibacterial and/or cancer treatment, comprising administering to an animal in need thereof the nanoparticles prepared by the method of claim 1 .

15. The method of claim 14 , wherein the nanoparticles are administered with photothermal therapy in treatment of Ehrlich Ascites carcinoma cells.

16. The method of claim 9 wherein the surfactant is cetyl trimethyl ammonium bromide (CTAB).

Assignees

• Univ King Saud

Inventors

• Hendi Awatif Ahmed
• Awad Manal A
• Eisa Nada E
• Ortashi Khaled M

Classifications

• B22F1/054

  Nanosized particles · CPC title

• B22F9/24 Primary

  starting from liquid metal compounds, e.g. solutions · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• Y10T428/2982

  Particulate matter [e.g., sphere, flake, etc.] · CPC title

• A61K33/38

  Silver; Compounds thereof · CPC title