Molecules that bind to cd94/nkg2a heterodimer polypeptides
US-2024415889-A1 · Dec 19, 2024 · US
Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
US9458236B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9458236-B2 |
| Application number | US-201314055222-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 16, 2013 |
| Priority date | Jun 13, 2001 |
| Publication date | Oct 4, 2016 |
| Grant date | Oct 4, 2016 |
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Abstract
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Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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We claim: 1. An isolated human monoclonal antibody which binds to human EGFR comprising heavy and light chain variable regions, wherein the heavy chain variable region is encoded by the nucleic acid set forth in SEQ ID NO: 1, or the light chain variable region is encoded by the nucleic acid sequence set forth in SEQ ID NO: 3. 2. An isolated human monoclonal antibody which binds to human EGFR comprising heavy and light chain variable regions, wherein the heavy ch…
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- What does patent US9458236B2 cover?
- Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also d…
- Who is the assignee on this patent?
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- What technology area does this patent fall under?
- Primary CPC classification C07K16/2863. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 04 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).