Crystalline sodium salt of an HIV integrase inhibitor

Patent metadata

Field	Value
Publication number	US-9458146-B2
Application number	US-201214115316-A
Country	US
Kind code	B2
Filing date	Apr 27, 2012
Priority date	May 3, 2011
Publication date	Oct 4, 2016
Grant date	Oct 4, 2016

Abstract

A crystalline sodium salt of a compound of formula I (INN: Raltegravir)

or a hydrate/solvate thereof is disclosed as well as a process for obtaining the same.

First claim

The invention claimed is:

1. A crystalline sodium salt of a compound of formula I (INN: Raltegravir)

or a hydrate/solvate thereof.

2. The crystalline compound of claim 1 , characterized in that the molar ratio of the compound of formula I and sodium is in the range of from 1:0.5 to 1:1.

3. The crystalline compound of claim 1 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 5.7°, 7.3°, 8.0°, 18.0° and 21.8°, designated as form A.

4. The crystalline compound of claim 3 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 20θ (CuKα radiation)) at 5.7°, 7.3°, 8.0°, 11.8°, 16.7°, 18.0°, 18.6°, 19.4°, 21.1° and 21.8°.

5. The crystalline compound according to claim 3 , characterized in that it has a FT-Raman spectrum comprising peaks at wavenumbers (expressed in ±2 cm −1 ) of 637, 692, 850, 1051, 1218, 1261, 1298, 1335, 1410, 1550, 1570, 1630, 1664, 1690, 2937 and 3073 cm −1 .

6. The crystalline compound of claim 1 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 5.7°, 7.0° and 20.9°, designated as form B.

7. The crystalline compound of claim 6 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 5.7°, 7.0°, 7.7°, 15.4°, 17.9°, 20.9° and 21.7°.

8. The crystalline compound according to claim 6 , characterized in that it has a FT-Raman spectrum comprising peaks at wavenumbers (expressed in ±2 cm −1 ) of 636, 700, 847, 1054, 1203, 1263, 1298, 1336, 1410, 1521, 1550, 1572, 1605, 1663, 2941 and 3069 cm −1 .

9. The crystalline compound of claim 1 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 5.5°, 7.0°, 8.0° and 20.8°, designated as form C.

10. The crystalline compound of claim 9 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2 θ (CuKα radiation)) at 5.5°, 7.0°, 8.0°, 18.0°, 18.5° and 20.8°.

11. The crystalline compound according to claim 9 , characterized in that it has a FT-Raman spectrum comprising peaks at wavenumbers (expressed in ±2 cm −1 ) of 636, 828, 1049, 1203, 1299, 1336, 1408, 1546, 1571, 2935, 3073 cm −1 .

12. The crystalline compound of claim 1 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2 θ (CuKα radiation)) at 4.2°, 6.0°, 6.8°, 8.5° and 19.3°, designated as form D.

13. The crystalline compound of claim 12 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 4.2°, 6.0°, 6.8°, 8.5°, 12.7°, 13.5°, 17.0°, 17.9°, 19.3°, 21.5° and 24.7°.

14. The crystalline compound of claim 1 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2 θ (CuKα radiation)) at 4.1°, 5.9°, 6.3° and 19.1°, designated as form E.

15. The crystalline compound of claim 1 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 5.0°, 5.7°, 18.6° and 20.4°, designated as form F.

16. The crystalline compound of claim 1 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 5.3°, 6.0° and 12.2°, designated as form G.

17. The crystalline compound of claim 1 , characterized in that it has an XRPD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 5.9°, 6.4°, 7.0° and 8.6°, designated as form H.

18. A process for obtaining the crystalline compound according to claim 1 comprising the steps of:
a) providing a compound of formula I (INN: Raltegravir)

in a suitable solvent or a mixture of solvents;

b) adding an aqueous solution comprising sodium hydroxide to the mixture of step a);
c) optionally concentrating the composition of step b);
d) crystallizing;
e) optionally equilibrating the obtained suspension of step d); and
f) isolating the obtained precipitate.

19. The process of claim 18 , characterized in that the molar ratio of the compound of formula I in step a) and the sodium hydroxide of step b) is in the range of from 1:0.5 to 1:1.2.

20. A process for obtaining a crystalline compound according to claim 1 comprising the steps of:
a) providing a sodium salt of a compound of formula I (INN: Raltegravir)

b) adding a suitable solvent or mixture of solvents to the compound of step a);
c) optionally concentrating the composition of step b);
d) crystallizing;
e) optionally equilibrating the obtained suspension of step d); and
f) isolating the obtained precipitate.

21. The process of claim 18 , characterized in that in step c) the solvent is removed and the residue is dissolved in a suitable solvent or mixture of solvents and water.

22. The process of claim 18 , characterized in that the solvent is selected from the group consisting of C2-C4 alcohols, a C3-C6 ketone, an ether or an acetic ester, C1-C4 alkylester, acetonitrile, a hydrocarbon and mixtures thereof.

23. The process of claim 18 , characterized in that in step d) seed crystals are added.

24. A pharmaceutical composition comprising the crystalline compound according to claim 1 and optionally one or more pharmaceutically acceptable excipients.

25. A method for the treatment or prevention of an infection by HIV and/or the treatment or prevention or delay of the onset of AIDS, the method comprising administering to a subject in need thereof an effective amount of the crystalline compound of claim 1 .

Assignees

• Blatter Frtiz
• Reichenbächer Katharina
• Ziegert Robert
• Wieser Josef
• Ludescher Johannes
• Sandoz Ag

Inventors

• Blatter Frtiz
• Reichenbächer Katharina
• Ziegert Robert
• Wieser Josef
• Ludescher Johannes

Classifications

• C07D413/12 Primary

  linked by a chain containing hetero atoms as chain links · CPC title

• A61P31/18

  for HIV · CPC title