Aryl ureas with angiogenisis inhibiting activity
US-2016015697-A1 · Jan 21, 2016 · US
Process for the preparation of 4-{4-[({[4 chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorphenoxy-N-ethylpyridie-carboxamide, its salts and monohydrate
US9458107B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9458107-B2 |
| Application number | US-201414252850-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 15, 2014 |
| Priority date | Apr 15, 2010 |
| Publication date | Oct 4, 2016 |
| Grant date | Oct 4, 2016 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy)-N-methylpyridine-2-carboxamide, its salts and monohydrate.
First claim
Opening claim text (preview).
What is claimed is: 1. The compound of the formula (I) which is contaminated with one or more anilinic substances, each in an amount equal to or less than 0.05% by weight based on the weight of the compound of the formula (I). 2. The compound of claim 1 which is contaminated with 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide each in an amount equal to or less than 0.05% by weight based on the weight of the compound of the formula (I). 3. A composition comprising the compound of the formula (I) the monohydrate of the compound of formula (I) or a combination thereof, which comprises one or more anilinic substances, each in an amount equal to or less than 0.05% by weight, based on the amount of the compound of formula (I) within the composition, wherein the amount of the compound of formula (I) within the composition comprises the combined weight of the compound of formula (I) and the calculated weight of the compound of formula I from the monohydrate of the compound of formula (I) within the composition. 4. The composition of claim 3 which comprises 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide each in an amount equal to or less than 0.05% by weight, based on the amount of the compound of formula (I) within the composition. 5. A composition comprising a combination of the compound of formula (I) and the monohydrate of the compound of formula (I), which comprises one or more anilinic substances, each in an amount equal to or less than 0.05% by weight based on the amount of the compound of formula (I) within the composition wherein the amount of the compound of formula (I) within the composition comprises the combined weight of the compound of formula (I) and the calculated weight of the compound of formula I from the monohydrate of the compound of formula (I) within the composition. 6. The composition of claim 5 which comprises 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide, each in an amount equal to or less than 0.05% by weight, based on the amount of the compound of formula (I) within the composition. 7. A combination of a compound of formula (I) and its monohydrate contaminated with one or more anilinic substances, each in an amount equal to or less than 0.05% by weight, based on the amount of the compound of the formula (I) within the combination, wherein the amount of the compound of formula (I) within the combination comprises the combined weight of the compound of formula (I) and the calculated weight of the compound of formula I from the monohydrate of the compound of formula (I) within the combination. 8. A combination of claim 7 contaminated with 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide each in an amount equal to or less than 0.05% by weight based on the amount of the compound of the formula (I). 9. The compound of the formula (I) which is contaminated with 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamide, each in an amount of from 0.0001% to a maximum of 0.05% by weight, based on the weight of the compound of the formula (I). 10. The compound of the formula (I) of claim 9 which is contaminated with 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide, each in an amount of from 0.0001% to a maximum of 0.025% by weight, based on the weight of the compound of the formula (I). 11. The compound of the formula (I) which is contaminated with 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamide, each in an amount of from 0.0001% to a maximum of 0.01% by weight, based on the weight of the compound of the formula (I). 12. A composition comprising the compound of the formula (I) which comprises 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide, each in an amount 0.0001% to a maximum of 0.05% by weight, based on the weight of the compound of the formula (I) within the composition. 13. A composition of claim 12 which comprises 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide, each in an amount 0.0001% to a maximum of 0.025% by weight, based on the weight of the compound of the formula (I) within the composition. 14. A composition comprising the compound of the formula (I) which comprises 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide, each in an amount 0.0001% to a maximum of 0.01% by weight, based on the weight of the compound of the formula (I) within the composition. 15. A composition comprising a combination of the compound of the formula (I) and the monohydrate of the compound of formula (I), which comprises 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide, each in an amount of from 0.0001% to a maximum of 0.05% by weight, based on the amount of the compound of the formula (I) within the composition, wherein the amount of the compound of formula (I) within the composition comprises the combined weight of the compound of formula (I) and the calculated weight of the compound of formula I from the monohydrate of the compound of formula (I) within the composition. 16. A composition of claim 15 which comprises 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide, each in an amount 0.0001% to a maximum of 0.025% by weight, based on the amount of the compound of the formula (I) within the composition. 17. A composition comprising a combination of the compound of the formula (I) and the monohydrate of the compound of formula (I), which comprises 4-amino-3-fluorophenol and/or 4-(4-amino-3-fluorophenoxy)pyridine2-carboxylic acid methylamide each in an amount of from 0.0001% to a maximum of 0.01% by weight based on the amount of the compound of the formula (I), wherein the amount of the compound of formula (I) within the composition comprises the combined weight of the compound of formula (I) and the calculated weight of the compound of formula I from the monohydrate of the compound of formula (I). 18. A composition comprising the compound of the formula (I) the monohydrate of the compound of formula (I), a salt of the compound of
Assignees
Inventors
Classifications
Antineoplastic agents · CPC title
specific for leukemia · CPC title
- C07D213/81Primary
Amides; Imides · CPC title
having oxo groups directly attached to the heterocyclic ring · CPC title
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Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9458107B2 cover?
- The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy)-N-methylpyridine-2-carboxamide, its salts and monohydrate.
- Who is the assignee on this patent?
- Bayer Healthcare Llc, Bayer Ip Gmbh
- What technology area does this patent fall under?
- Primary CPC classification C07D213/81. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 04 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).