Back-end device for an auto-injector and auto-injector

Patent metadata

Field	Value
Publication number	US-9457149-B2
Application number	US-201113996420-A
Country	US
Kind code	B2
Filing date	Dec 21, 2011
Priority date	Dec 21, 2010
Publication date	Oct 4, 2016
Grant date	Oct 4, 2016

Abstract

According to the invention, a back-end device of an auto-injector adapted to be attached to a packaged syringe comprises
a plunger arranged to abut against a stopper of the packaged syringe to translate an injection needle of the packaged syringe in a proximal direction and to expel a dose of a medicament contained in the packaged syringe through the injection needle, a drive means capable of, upon release, driving the plunger in the proximal direction towards a proximal position, a rotary sleeve with a cam surface adapted to be engaged by a plunger follower formed to the plunger, a torsion spring arranged to exert a torque upon the rotary sleeve and a release element capable of, upon manual actuation, releasing the engagement of the plunger follower with the cam surface. The plunger follower is arranged to engage the cam surface to prevent the rotary sleeve from rotating with respect to the chassis in an initial state. Furthermore, in the initial state the plunger follower is arranged to engage the cam surface to prevent an axial translation of the plunger in the proximal direction. Upon release of the engagement of the plunger follower with the cam surface, the rotary sleeve is arranged to rotate within the chassis. The cam surface re-engages the plunger follower after a time delay determined by a rotation speed of the rotary sleeve. The time delay is set so as to allow the cam surface to re-engage the plunger follower after the plunger reaches the proximal position. The cam surface is arranged to withdraw the plunger from the proximal position in a distal direction by continued rotation of the rotary sleeve.

First claim

The invention claimed is:

1. A back-end device of an auto-injector adapted to be attached to a packaged syringe, the back-end device comprising:
a chassis,
a plunger arranged to abut against a stopper of the packaged syringe to translate an injection needle of the packaged syringe in a proximal direction and to expel a dose of a medicament contained in the packaged syringe through the injection needle,
a drive spring capable of, upon release, driving the plunger in the proximal direction towards a proximal position,
a rotary sleeve with a cam surface adapted to be engaged by a plunger follower formed to the plunger,
a torsion spring arranged to exert a torque upon the rotary sleeve, the torsion spring being configured to bias the rotary sleeve to rotate, and
a release element comprising a push button, the release element being capable of, upon manual actuation, releasing the engagement of the plunger follower with the cam surface,

wherein the plunger follower is arranged to engage the cam surface to inhibit the rotary sleeve from rotating with respect to the chassis and to inhibit an axial translation of the plunger in the proximal direction in an initial state,
wherein, upon release of the engagement of the plunger follower with the cam surface, the rotary sleeve is arranged to rotate within the chassis so that the cam surface re-engages the plunger follower after a time delay determined by a rotation speed of the rotary sleeve, the time delay being set to allow the cam surface to re-engage the plunger follower after the plunger reaches the proximal position, and
wherein the cam surface is arranged to withdraw the plunger from the proximal position in a distal direction by continued rotation of the rotary sleeve.

2. The back-end device according to claim 1 , further comprising a rotary damper arranged to exert a velocity dependent torque upon the rotary sleeve to restrict a maximal rotation speed of the rotary sleeve.

3. The back-end device according to claim 2 , wherein the rotary damper comprises a first cog wheel configured to engage a second cog wheel of the rotary sleeve.

4. The back-end device according to claim 1 , further comprising a sleeve latch rotationally affixed to the chassis,
wherein the sleeve latch arranged to engage the rotary sleeve to inhibit the rotary sleeve from rotating within the chassis when the sleeve latch is in a locked position, and
wherein the sleeve latch is arranged to be translated in the distal direction into an unlocked position such that the sleeve latch disengages from the rotary sleeve to allow for a rotation of the rotary sleeve within the chassis when the sleeve latch is in the unlocked position.

5. The back-end device according to claim 4 , wherein the sleeve latch is biased towards the locked position by a biasing element.

6. The back-end device according to claim 1 , wherein the release element comprises a chamfered surface configured to abut against a projection of the rotary sleeve so that, upon manual actuation, the release element exerts a torque upon the rotary sleeve to release the engagement of the plunger follower with the cam surface.

7. The back-end device according to claim 1 , wherein the plunger is hollow, and the drive spring is substantially arranged within the plunger.

8. The back-end device according to claim 1 , wherein a modulus of resilience of the drive spring and a modulus of resilience of the torsion spring are selected such that the time delay allows the cam surface to re-engage the plunger follower after the plunger reaches the proximal position.

9. The back-end device according to claim 1 , wherein a distal portion of the cam surface defines a latch configured to inhibit the axial translation of the plunger, and the plunger follower is configured to disengage from the latch when the rotary sleeve is rotated relative to the plunger.

10. The back-end device according to claim 1 , wherein the plunger follower and the cam surface are configured such that a friction force between the plunger follower and the cam surface exceeds a preload of the torsion spring to inhibit the axial translation of the plunger in the proximal direction in the initial state.

11. An auto-injector comprising:
a reusable back-end device and a packaged syringe attached to a proximal end of the back-end device,
wherein the packaged syringe comprises
a syringe barrel containing a dose of a medicament,
a stopper fluid-tightly sealing a distal end of the syringe barrel, and
an injection needle in fluid communication with an interior of the syringe barrel,

wherein the reusable back-end device comprises
a chassis,
a plunger arranged to abut against the stopper of the packaged syringe to translate the injection needle of the packaged syringe in a proximal direction and to expel the dose of the medicament contained in the packaged syringe through the injection needle,
a drive spring capable of, upon release, driving the plunger in the proximal direction towards a proximal position,
a rotary sleeve with a cam surface adapted to be engaged by a plunger follower formed to the plunger,
a torsion spring arranged to exert a torque upon the rotary sleeve, the torsion spring being configured to bias the rotary sleeve to rotate, and
a release element comprising a push button, the release element being capable of, upon manual actuation, releasing the engagement of the plunger follower with the cam surface,
wherein the plunger follower is arranged to engage the cam surface to inhibit the rotary sleeve from rotating with respect to the chassis and to inhibit an axial translation of the plunger in the proximal direction in an initial state,
wherein, upon release of the engagement of the plunger follower with the cam surface, the rotary sleeve is arranged to rotate within the chassis so that the cam surface re-engages the plunger follower after a time delay determined by a rotation speed of the rotary sleeve, the time delay being set to allow the cam surface to re-engage the plunger follower after the plunger reaches the proximal position,
wherein the cam surface is arranged to withdraw the plunger from the proximal position in a distal direction by continued rotation of the rotary sleeve, and
wherein the plunger in the proximal position abuts against the stopper and is arranged to be withdrawn from the proximal position in the distal direction.

12. The auto-injector according to claim 11 , further comprising a syringe retainer slidably arranged with respect to a transfer sleeve, the transfer sleeve being configured to releasably mount the packaged syringe to the chassis of the back-end device.

13. The auto-injector according to claim 12 , further comprising a sleeve latch rotationally affixed to the chassis,
wherein the transfer sleeve is adapted to rest on skin of a patient during an injection, the transfer sleeve being configured to abut against the sleeve latch so that the sleeve latch is translatable from a locked position to an unlocked position by a distal translation of the transfer sleeve with respect to the syringe retainer, and
wherein the sleeve latch is rotationally affixed to the chassis and is configured to engage the rotary sleeve to inhibit the rotary sleeve from rotating within the chassis when the sleeve latch is in the locked position, and the sleeve latch is configured to disengage from the rotary sleeve to allow for a rotation of the rotary sleeve within the chassis when the sleeve latch is in the unlocked position.

14. The auto-injector according to claim 12 , further comprising a support sleeve to which the syringe barrel is mounted, wherein the support sleeve i

Assignees

• Kemp Thomas Mark
• Jennings Douglas
• Ekman Matthew
• Sanofi Aventis Deutschland

Inventors

• Kemp Thomas Mark
• Jennings Douglas
• Ekman Matthew

Classifications

• A61M2005/2086

  having piston damping means, e.g. axially or rotationally acting retarders · CPC title

• A61M2005/208

  Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin · CPC title

• A61M5/24

  Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic {(ampoules or carpules A61J1/06)} · CPC title

• A61M5/326

  Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user · CPC title

• A61M5/46

  having means for controlling depth of insertion · CPC title