Method and composition for sterilization of a polymerizable monomer

Patent metadata

Field	Value
Publication number	US-9457110-B2
Application number	US-201213681996-A
Country	US
Kind code	B2
Filing date	Nov 20, 2012
Priority date	Nov 22, 2011
Publication date	Oct 4, 2016
Grant date	Oct 4, 2016

Abstract

A method is provided for sterilization of a polymerizable monomer, in which the mixture contains at least the polymerizable monomer, a compound (a), and a compound (b). Compound (a) is selected from the group of compounds (a1), compounds (a2), and compounds (a3), wherein compounds (a1) are represented by general formula (I):

wherein R1, R2, R3, and R4, independent of each other, represent a substituted alkyl residue, a non-substituted alkyl residue, a halogen, a nitro group, or a cyano group; compounds (a2) are selected from the group of dimers of compounds (a1); and compounds (a3) are selected from the group of dialkyldicarbonates. Compound (b) is selected from the group of water and alcohols.

First claim

I claim:

1. A method for sterilization of a polymerizable monomer, the method comprising mixing at least the polymerizable monomer, an acylating agent, and a compound (b), wherein:
(i) the acylating agent is selected from one of compounds (a1), (a2), and (a3), wherein compound (a1) is a compound represented by formula (I):

wherein R1, R2, R3, and R4 independently represent a hydrogen, a substituted alkyl residue, a non-substituted alkyl residue, a halogen, a nitro group, or a cyano group;
wherein compound (a2) is selected from the group consisting of dimers of compounds (a1); and
wherein compound (a3) is selected from the group consisting of dialkyldicarbonates; and

(ii) the compound (b) is selected from the group consisting of water and alcohols, thereby producing a paste, such that the polymerizable monomer is sterilized in the paste, and wherein a fraction of compound (b) in the paste is no more than 2% by weight relative to a total weight of the paste.

2. The method according to claim 1 , wherein a fraction of compound (b) in the paste is no more than 0.4% by weight, relative to the total weight of the paste.

3. The method according to claim 1 , wherein the polymerizable monomer is a monomer for radical polymerization.

4. The method according to claim 1 , wherein the acylating agent is β-propiolactone.

5. The method according to claim 1 , wherein the polymerizable monomer and compound (b) are the same compound.

6. The method according to claim 1 , wherein a ratio of the quantity n b of compound (b) in the paste to the quantity n a of the acylating agent in the paste is represented by the equation n b /n a >0.5.

Assignees

• Heraeus Medical Gmbh

Inventors

• Vogt Sebastian

Classifications

• A61L2/16

  using chemical substances · CPC title

• C08L33/26

  Homopolymers or copolymers of acrylamide or methacrylamide · CPC title

• A61L24/043

  Mixtures of macromolecular materials · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title

• A61L24/046 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds (A61L24/043 takes precedence) · CPC title