Antibacterial protein kinase inhibitors

Patent metadata

Field	Value
Publication number	US-9457031-B2
Application number	US-201314418250-A
Country	US
Kind code	B2
Filing date	Jul 30, 2013
Priority date	Jul 30, 2012
Publication date	Oct 4, 2016
Grant date	Oct 4, 2016

Abstract

Methods of treating bacterial infection by in a subject by administering a pharmaceutical composition including a celecoxib derivative are described. The compounds are particularly useful for treating infection by bacteria capable of growing inside macrophages, such as Myocobacteria tuberculosis.

First claim

What is claimed is:

1. A compound of formula I:

wherein R 1 is selected from —NH 2 , —CO 2 H, —CO 2 Me, —CONH 2 , —CONHNH 2 , —CONHMe, —CO-piperazine, —CO-pyrrolidine, —CONH-glycine, —CH 2 CH 2 CO 2 Me, —CH 2 CH 2 CONH—C 1 -C 4 alkyl, —NHCO—C 1 -C 4 alkyl, —NHSO 2 NH 2 , —NHSO 2 N(Me) 2 , —NHCONH—C 1 -C 4 alkyl, —NHCONH 2 , —NHCO 2 —C 1 -C 4 alkyl;
Ar is a substituted or unsubstituted phenyl, biphenyl, naphthalenyl, or anthracenyl group;
X is C═O or O═S═O, and
R 2 is a substituted or unsubstituted cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group, or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein R 1 is —CH 2 CH 2 CONH-Me and Ar is 4′-trifluoromethyl biphenyl.

Assignees

• Univ Ohio State

Inventors

• Chen Ching-Shih
• Salunke Santosh
• Schlesinger Larry
• Azad Abul K

Classifications

• A61K31/496

  Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• C07D403/10

  linked by a carbon chain containing aromatic rings · CPC title

• A61P31/06

  for tuberculosis · CPC title

• A61K31/4178

  not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin · CPC title