Use of Bifidobacterium longum for the prevention and treatment of inflammation

Patent metadata

Field	Value
Publication number	US-9456630-B2
Application number	US-201213451837-A
Country	US
Kind code	B2
Filing date	Apr 20, 2012
Priority date	Feb 15, 2006
Publication date	Oct 4, 2016
Grant date	Oct 4, 2016

Abstract

The invention relates to the use, in the manufacture of a medicament or a therapeutic nutritional composition for preventing or reducing inflammation in a mammal, of bifidobacterium longum ATCC BAAA-999.

First claim

The invention is claimed as follows:

1. A method of treating a patient having intestinal inflammation due to food allergies, the method comprising administering to the patient a nutritional composition comprising (i) Bifidobacterium longum ATCC BAA-999 in an amount from 10 8 to 10 12 cfu/g of the nutritional composition on a dry weight basis, (ii) a fat source that provides 5% to 55% of the energy of the nutritional composition, and (iii) a carbohydrate source that provides 40% to 80% of the energy of the nutritional composition.

2. The method of claim 1 , wherein the patient is a human.

3. A method of treating a patient having an illness selected from the group consisting of a reaction to a food allergen, chronic sub-clinical inflammation in the elderly, and inflammation where there is no underlying condition giving rise to the inflammation, the method comprising administering to the patient a nutritional composition comprising Bifidobacterium longum ATCC BAA-999 in an amount from 10 8 to 10 12 cfu/g of the nutritional composition on a dry weight basis, (ii) a fat source that provides 5% to 55% of the energy of the nutritional composition, and (iii) a carbohydrate source that provides 40% to 80% of the energy of the nutritional composition.

4. The method of claim 3 , wherein the illness of the patient is a reaction to a food allergen.

5. The method of claim 3 , wherein the patient is elderly, and the illness of the patient is chronic sub-clinical inflammation.

6. The method of claim 3 , wherein the illness of the patient is inflammation where there is no underlying condition giving rise to the inflammation.

7. The method of claim 3 , wherein the patient is a human.

8. A method of treating a patient having an illness selected from the group consisting of a reaction to a food allergen, chronic sub-clinical inflammation in the elderly, and inflammation where there is no underlying condition giving rise to the inflammation, the method comprising:
rendering Bifidobacterium longum ATCC BAA-999 non-replicating by a heat treatment at about 80° C. to about 110° C. for about 5 seconds to about 5 minutes; and
administering a nutritional composition to the patient, the nutritional composition comprising the non-replicating Bifidobacterium longum ATCC BAA-999 in an amount from 10 8 to 10 12 cfu/g of the nutritional composition on a dry weight basis, (ii) a fat source that provides 5% to 55% of the energy of the nutritional composition, and (iii) a carbohydrate source that provides 40% to 80% of the energy of the nutritional composition.

9. The method of claim 8 , wherein the patient is a human.

Assignees

• Mercenier Annick
• Blum-Sperisen Stephanie
• Rochat Florence
• Nestec Sa

Inventors

• Mercenier Annick
• Blum-Sperisen Stephanie
• Rochat Florence

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P1/00

  Drugs for disorders of the alimentary tract or the digestive system · CPC title

• A23K50/40

  for carnivorous animals, e.g. cats or dogs · CPC title

• A23K10/18

  of live microorganisms · CPC title

• A23L33/135 Primary

  Bacteria or derivatives thereof, e.g. probiotics · CPC title