Methods and nucleic acid molecules for aav vector selection
US-2024417717-A1 · Dec 19, 2024 · US
US9453056B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9453056-B2 |
| Application number | US-201214342129-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 31, 2012 |
| Priority date | Aug 31, 2011 |
| Publication date | Sep 27, 2016 |
| Grant date | Sep 27, 2016 |
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A nucleic acid includes, in the following order, a 5′ untranslated region comprising a particular nucleotide sequence of the genome of hepatitis C virus genotype 3a; a nucleotide sequence encoding a particular amino acid sequence of an NS3 protein, a nucleotide sequence encoding a particular amino acid sequence of an NS4A protein, a nucleotide sequence encoding a particular amino acid sequence of an NS4B protein, a nucleotide sequence encoding a particular amino acid sequence of an NS5A protein, a nucleotide sequence encoding a particular amino acid sequence of an NS5B protein of the hepatitis C virus genotype 3a; and a 3′ untranslated region comprising a particular nucleotide sequence of a genome of hepatitis C virus genotype 3a.
Opening claim text (preview).
The invention claimed is: 1. A nucleic acid comprising, in the following order, a 5′ untranslated region comprising a nucleotide sequence of nucleotides 1 to 340 of SEQ ID NO: 1; a nucleotide sequence encoding an amino acid sequence of an NS3 protein of amino acids 1033 to 1663, a nucleotide sequence encoding an amino acid sequence of an NS4A protein of amino acids 1664 to 1717, a nucleotide sequence encoding an amino acid sequence of an NS4B protein of amino acids 1718 to 1978, a…
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