Oligomeric compounds and methods
US-8987435-B2 · Mar 24, 2015 · US
Nucleic acid chemical modifications
US9453043B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9453043-B2 |
| Application number | US-201514602749-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 22, 2015 |
| Priority date | Mar 2, 2009 |
| Publication date | Sep 27, 2016 |
| Grant date | Sep 27, 2016 |
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Abstract
Official abstract text for this publication.
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
First claim
Opening claim text (preview).
The invention claimed is: 1. A nucleoside of formula (1): wherein: one of D 1 and D 2 is H, or a hydroxyl protecting group, and the other of D 1 and D 2 is H, a hydroxyl protecting group, or a reactive phosphorus group, provided that when one of D 1 and D 2 is a reactive phosphorus group, the other of D 1 and D 2 is a hydroxyl protecting group; m is an integer…
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Classifications
- C07H19/073Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07H21/02Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9453043B2 cover?
- The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a tim…
- Who is the assignee on this patent?
- Alnylam Pharmaceuticals Inc
- What technology area does this patent fall under?
- Primary CPC classification C07H19/073. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 27 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).