Methylphenidate-oxoacid conjugates, processes of making and using the same
US-9079928-B2 · Jul 14, 2015 · US
Methylphenidate-prodrugs, processes of making and using the same
US9453037B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9453037-B2 |
| Application number | US-201514727498-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 1, 2015 |
| Priority date | Jul 28, 2011 |
| Publication date | Sep 27, 2016 |
| Grant date | Sep 27, 2016 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
First claim
Opening claim text (preview).
The invention claimed is: 1. A composition comprising: at least one conjugate of methylphenidate, wherein the conjugate of methylphenidate has the following structure: wherein G 2 is independently selected from the group consisting of standard amino acids, nonstandard amino acids and synthetic amino acids, wherein the amino acid is attached to the rest of the molecule by an amide linkage. 2. The composition of claim 1 , wherein G 2 is selected from the group consisting of Phe, His, Ile, and Pro. 3. The composition of claim 1 , wherein the conjugate of methylphenidate has the following structure: 4. The composition of claim 1 , wherein the conjugate of methylphenidate is Phe-(6-aminohexanoyl)-CH 2 OCO-MPH. 5. A composition comprising: at least one conjugate of methylphenidate, wherein the conjugate of methylphenidate has the following structure: wherein G 2 and G 3 are independently selected from the group consisting of standard amino acids, nonstandard amino acids and synthetic amino acids, wherein the amino acid is attached to the rest of the molecule by an amide linkage. 6. The composition of claim 5 , wherein G 2 and G 3 are independently selected from the group consisting of Phe and Pro.
Assignees
Inventors
Classifications
Antiarrhythmics · CPC title
Drugs for disorders of the endocrine system · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Drugs for disorders of the cardiovascular system · CPC title
General protective or antinoxious agents · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9453037B2 cover?
- The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methyl…
- Who is the assignee on this patent?
- Kempharm Inc, Kempharm Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/4458. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 27 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).