Para-hydrogen polarizer

Patent metadata

Field	Value
Publication number	US-9452409-B2
Application number	US-201214113325-A
Country	US
Kind code	B2
Filing date	Apr 22, 2012
Priority date	Apr 22, 2011
Publication date	Sep 27, 2016
Grant date	Sep 27, 2016

Abstract

A reactor assembly comprising a reservoir, a reaction chamber, and a valve assembly comprising at least one valve. The reservoir, reaction chamber, and valve assembly are non-magnetic. The valve assembly is adapted to selectively provide fluid communication between the reservoir and the reaction chamber.

First claim

What is claimed is:

1. A reactor assembly comprising:
a reservoir
a reaction chamber;
a valve assembly comprising at least one valve, wherein the valve assembly is adapted to selectively provide fluid communication between the reservoir and the reaction chamber and is adapted to withstand pressures of at least 500 psi;
a magnet adapted to produce a static magnetic field having a magnitude of at least about 1 mT; and
a radiofrequency pulse generator adapted to produce an applied magnetic field;
wherein the reservoir, reaction chamber, and valve assembly are non-magnetic and are positioned within the static magnetic field when the magnet is producing the static magnetic field;
wherein the reaction chamber is positioned within the applied magnetic field when the radiofrequency pulse generator is producing the applied magnetic field;
wherein the at least one valve comprises a housing having an inner wall defining an internal space and a piston assembly positioned within the space and movable relative to the housing between a first position and a second position;
wherein the housing comprises a first opening at a first end and a second opening at a second end opposite the first end;
wherein the piston assembly translates to the first position in response to a first fluid pressure applied via the first opening; and
wherein the piston assembly translates to the second position in response to a second fluid pressure applied via the second opening; and
wherein the piston assembly further comprises a first end, a second end, a channel and at least one sealing member on each side of the channel, wherein the application of a net compressive force to the first and second ends causes at least a portion of each sealing member to move towards the inner wall of the housing, thereby preventing or inhibiting fluids from flowing between the sealing member and the inner wall of the housing.

2. The reactor assembly of claim 1 , wherein the at least one valve comprises a spool valve.

3. The reactor assembly of claim 1 , wherein the housing further comprises a third opening in fluid communication with the reaction chamber and a fourth opening in fluid communication with the reservoir,
wherein the third opening and fourth opening are located in the side of the housing;
wherein the piston assembly is adapted to provide fluid communication between the third opening and fourth opening when the piston assembly is in the first position; and
wherein the piston assembly is adapted to prevent fluid communication between the third opening and fourth opening when the piston assembly is in the second position.

4. The reactor assembly of claim 1 , wherein the housing further comprises a fifth opening in fluid communication with an external source or an output and a sixth opening in fluid communication with the reaction chamber,
wherein the fifth opening and sixth opening are located in the side of the housing;
wherein the piston assembly is adapted to provide fluid communication between the fifth opening and sixth opening when the piston assembly is in the second position; and
wherein the piston assembly is adapted to prevent fluid communication between the fifth opening and sixth opening when the piston assembly is in the first position.

5. The reactor assembly of claim 1 , wherein each sealing member engages the inner wall of the housing with a force having a magnitude that is proportional to the magnitude of the compressive force applied to the first and second ends.

6. The reactor assembly of claim 1 , wherein during translation of the piston assembly between the first and second position, the at least one sealing member engages the inner wall of the housing with sufficient force to wipe liquids from the inner wall of the housing, but with insufficient force to prevent translation of the piston assembly.

7. The reactor assembly of claim 1 , wherein the piston assembly further includes a curved edge adjacent to and corresponding to each sealing member, and wherein application of a net compressive force to the first and second ends causes each sealing member to engage the corresponding curved edge, which thereby forces the sealing member to move toward the inner wall of the housing.

8. The reactor assembly of claim 1 , wherein the valve assembly is adapted to withstand pressures of at least 1000 psi.

9. The reactor assembly of claim 1 , wherein the reservoir comprises a first piston, wherein the reaction chamber comprises a second piston, and wherein the first piston and second piston are fluid actuated.

10. The reactor assembly of claim 1 , wherein the reservoir, reaction chamber, and valve assembly are plastic.

11. The reactor assembly of claim 1 , wherein the valve assembly is adapted to channel fluids from the reservoir to the reaction chamber in less than about 1 second.

12. The reactor assembly of claim 1 , comprising a plurality of valves.

Assignees

• Waddell Kevin W
• Univ Vanderbilt

Inventors

• Waddell Kevin W

Classifications

• G01R33/282 Primary

  Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent · CPC title

• B01J19/087 Primary

  employing electric or magnetic energy · CPC title