Implant comprising an active-agent-containing coating covering the implant at least in sections

Patent metadata

Field	Value
Publication number	US-9452243-B2
Application number	US-201113306238-A
Country	US
Kind code	B2
Filing date	Nov 29, 2011
Priority date	Dec 8, 2010
Publication date	Sep 27, 2016
Grant date	Sep 27, 2016

Abstract

The invention relates to an implant comprising an active-agent-containing coating which covers the implant at least in sections. The coating is composed of at least two subsections; a first subsection contains the at least one active substance, and a second subsection contains an auxiliary agent.

First claim

What is claimed is:

1. An implant comprising a base body and a coating which covers the base body, the coating comprising least two adjacent subsections; a first subsection containing at least one active agent, and a second subsection containing an auxiliary agent, wherein at least one of the subsections is a polymer free section, further wherein the first subsection fills grooves in the second subsection thereby remaining partially uncovered and the second subsection is configured to dissolve after implantation thereby increasing exposure of the first subsection to a surrounding medium.

2. The implant according to claim 1 , wherein the individual subsections are designed such that the result is a pattern of alternating strips of the first and the second subsections.

3. The implant according to claim 2 , wherein one width of the strips that form the first subsection of the coating is in the range of 1 to 30 μm.

4. The implant according to claim 2 , wherein the pattern repeats.

5. The implant according to claim 1 , wherein the individual subsections are designed such that the result is a pattern of islands of the first subsection enclosed by the second subsection.

6. The implant according to claim 5 , wherein one width or one diameter of the islands that form the first subsection of the coating is in the range of 1 to 30 μm.

7. The implant according to claim 1 , wherein the base body of the implant is composed of a biocorrodible material.

8. The implant according to claim 7 , wherein the base body is composed of a biocorrodible magnesium alloy.

9. The implant according to claim 1 , wherein the active agent is selected from the group consisting of paclitaxel, sirolimus, a derivative of sirolimus, and one or more RAS inhibitors.

10. The implant according to claim 1 , wherein the auxiliary agent dissolves completely in vivo in fewer than 10 h.

11. The implant according to claim 10 , wherein the auxiliary agent comprises 80% or more by weight of a sugar or a sugar derivative.

12. The implant according to claim 1 , wherein the implant is a stent.

13. The implant according to claim 1 , wherein the first subsection is the polymer free section.

14. The implant according to claim 1 , wherein the second subsection is the polymer free section.

15. The implant according to claim 1 , wherein both the first and second subsections are polymer free.

16. The implant according to claim 1 , wherein both the first and second subsections form a closed coating preventing access to the base body.

Assignees

• Gratz Matthias
• Borck Alexander
• Rzany Alexander
• Schmiedl Robert
• Fringes Matthias
• Harder Claus
• Biotronik Ag

Inventors

• Gratz Matthias
• Borck Alexander
• Rzany Alexander
• Schmiedl Robert
• Fringes Matthias
• Harder Claus

Classifications

• A61L31/022

  Metals or alloys · CPC title

• A61L31/16 Primary

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• A61L31/08

  Materials for coatings · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title