Arrangement and method for heating of a magnetic material

Patent metadata

Field	Value
Publication number	US-9451900-B2
Application number	US-201013319351-A
Country	US
Kind code	B2
Filing date	Apr 19, 2010
Priority date	May 8, 2009
Publication date	Sep 27, 2016
Grant date	Sep 27, 2016

Abstract

The present invention relates to an arrangement ( 10 ) for heating of a magnetic material ( 100 ) located in the center region of an inscribed sphere within a region of action, which arrangement comprises: —selection means ( 210 ) for generating a magnetic selection field ( 211 ) having a pattern in space of its magnetic field strength such that a first sub-zone ( 301 ) having a low magnetic field strength and a second sub-zone ( 302 ) having a higher magnetic field strength are formed in the region of action ( 300 ), —drive means ( 220 ) for changing the position in space of the two sub-zones ( 301, 302 ) in the region of action ( 300 ) by means of a magnetic drive field ( 221 ) so that the magnetization of the magnetic material ( 100 ) changes locally, and —control means ( 76 ) for controlling the drive means ( 220 ) to change the position in space of the first sub-zone ( 301 ) along a sequence of locations around said inscribed sphere for so long and with such a frequency that the center region of said inscribed sphere is heated.

First claim

The invention claimed is:

1. An arrangement ( 10 ) for heating of a magnetic material ( 100 ) located in the centre region of an inscribed sphere within a region of action, which arrangement comprises:
selection means ( 210 ) for generating a magnetic selection field ( 211 ) having a pattern in space of its magnetic field strength such that a first sub-zone ( 301 ) having a low magnetic field strength and a second sub-zone ( 302 ) having a higher magnetic field strength are formed in the region of action ( 300 ),
drive means ( 220 ) for changing the position in space of the two sub-zones ( 301 , 302 ) in the region of action ( 300 ) by means of a magnetic drive field ( 221 ) so that the magnetization of the magnetic material ( 100 ) changes locally, and
control means ( 76 ) for controlling the drive means ( 220 ) to change the position in space of the first sub-zone ( 301 ) along a sequence of locations around said inscribed sphere for so long and with such a frequency that the centre region of said inscribed sphere is heated.

2. An arrangement ( 10 ) as claimed in claim 1 ,
wherein said control means ( 76 ) is adapted for controlling the drive means ( 220 ) to change the position in space of the first sub-zone ( 301 ) along a two-dimensional sequence of locations on a circle, around said inscribed sphere.

3. An arrangement ( 10 ) as claimed in claim 1 ,
wherein said control means ( 76 ) is adapted for controlling the drive means ( 220 ) to change the position in space of the first sub-zone ( 301 ) along a three-dimensional sequence of locations on a sphere, around said inscribed sphere.

4. An arrangement ( 10 ) as claimed in claim 1 ,
wherein said control means ( 76 ) is adapted for controlling the drive means ( 220 ) to change the position in space of the first sub-zone ( 301 ) with constant angular velocity.

5. An arrangement ( 10 ) as claimed in claim 1 ,
wherein said control means ( 76 ) is adapted for controlling the drive means ( 220 ) to change the position in space of the first sub-zone ( 301 ) with a frequency in the range from 1 to 100 kHz.

6. An arrangement ( 10 ) as claimed in claim 1 , further comprising:
receiving means ( 230 ) for acquiring detection signals, which detection signals depend on the magnetization in the region of action ( 300 ), which magnetization is influenced by the change in the position in space of the first and second sub-zone ( 301 , 302 ), and
processing means ( 74 ) for reconstructing an image of at least the centre region from the acquired detection signals.

7. An arrangement ( 10 ) as claimed in claim 1 ,
wherein magnetic material ( 100 ) comprises monodomain magnetic nanoparticles.

8. An arrangement ( 10 ) as claimed in claim 1 ,
wherein magnetic material ( 100 ) comprises monodomain magnetic nanoparticles encapsulated into liposomes, polymersomes or vesicles having an inner volume with viscosity equal or similar to that of water and separated by a hydrophobic membrane, wherein the magnetic particles are arranged in the inner volume.

9. An arrangement ( 10 ) as claimed in claim 1 ,
wherein said control means ( 76 ) is adapted for controlling the drive means ( 220 ) to change the position in space of the first sub-zone ( 301 ) with a frequency in the range from 10 to 30 kHz.

10. An arrangement ( 10 ) as claimed in claim 1 ,
wherein magnetic material ( 100 ) comprises colloidally stabilised monodomain magnetic nanoparticles encapsulated into liposomes, polymersomes or vesicles having an inner volume with viscosity equal or similar to that of water, and separated by a hydrophobic membrane, wherein the magnetic particles are arranged in the inner volume.

Assignees

• Boeve Hans Marc Bert
• Koninklijke Philips Nv

Inventors

• Boeve Hans Marc Bert

Classifications

• A61B5/0515

  Magnetic particle imaging · CPC title

• G01R33/1276

  of magnetic particles, e.g. imaging of magnetic nanoparticles (G01R33/1269 takes precedence) · CPC title

• A61B5/05 Primary

  Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves (measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24) · CPC title

• A61N1/403

  for thermotherapy, e.g. hyperthermia · CPC title

• A61N2/02

  using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) · CPC title