100Mo compounds as accelerator targets for production of 99mTc

Patent metadata

Field	Value
Publication number	US-9449726-B2
Application number	US-201414293599-A
Country	US
Kind code	B2
Filing date	Jun 2, 2014
Priority date	May 31, 2013
Publication date	Sep 20, 2016
Grant date	Sep 20, 2016

Abstract

Methods of synthesizing 100 Mo 2 C and 99m TcO 4 − are disclosed. Methods of 100 Mo 2 C generation involve thermally carburizing 100 MoO 3 . Methods of 99m TcO 4 generation involve proton bombardment of 100 Mo 2 C in a cyclotron. Yields of 99m TcO 4 can be increased by sintering 100 Mo 2 C prior to bombardment. The methods also include recycling of 100 Mo 2 C to form 100 MoO 3 . SPECT images obtained using 99m TcO 4 generated by the disclosed methods are also presented.

First claim

What is claimed is:

1. A method of synthesizing pertechnetate ( 99 TcO 4 − ), the method comprising: synthesizing 100 MO 2 C by thermally carburizing 100 MoO 3 ; and bombarding the 100 Mo 2 C with protons in a cyclotron to yield 99 TcO 4 − .

2. A method of synthesizing pertechnetate ( 99m TcO 4 − ) in accordance with claim 1 , further comprising purifying the 99m TcO 4 − by thermo-chromatography.

3. A method of synthesizing pertechnetate ( 99 TcO 4 − ) in accordance with claim 1 , wherein the thermally carburizing comprises:
(i) converting 100 MoO 3 to ammonium heptamolybdate tetrahydrate ((NH 4 ) 6 Mo 7 O 24 .4H 2 O) with 28% NH 3 (aq), (ii) converting (NH 4 ) 6 Mo 7 O 24 .4H 2 O to a hexamethyltetramine (HMT)-molybdate complex ((NH 4 ) 4 (HMT) 2 Mo 7 O 24 .4H 2 O) by reacting the (NH 4 ) 6 Mo 7 O 24 .4H 2 O with NH 3 (aq) and HMT and (iii) heating the dried HMT-molybdate complex in argon atmosphere to yield 100 Mo 2 C.

4. A method of synthesizing 99m Tc pertechnetate in accordance with claim 1 , wherein the bombarding the 100 Mo 2 C comprises bombarding the 100 Mo 2 C at a current of from about 1 μA, 1 μA up to 20 μA, or about 20 μA.

5. A method of synthesizing 99m Tc pertechnetate in accordance with claim 1 , wherein the bombarding the 100 Mo 2 C comprises bombarding the 100 Mo 2 C for about 45 minutes, from 45 minutes to 2 hours, or for about 2 hours.

6. A method of synthesizing 99m Tc pertechnetate in accordance with claim 1 , wherein the bombarding the 100 Mo 2 C comprises bombarding the 100 Mo 2 C at a current of about 20 μA for about 2 hours.

7. A method of synthesizing 99m Tc pertechnetate in accordance with claim 1 , further comprising collecting the 99m Tc 4 − in NaOH.

8. A method of synthesizing 99m Tc pertechnetate in accordance with claim 2 , wherein the thermo-chromatography comprises:
(i) conditioning the column with acidified water, (ii) passing NaOH containing 99m TcO 4 − through an ion-exchange column and (iii) eluting the column with a saline solution.

9. A method of synthesizing 99m Tc pertechnetate in accordance with claim 8 , wherein the acidified water has a pH of about 2.

10. A method of synthesizing 99m Tc pertechnetate in accordance with claim 1 , further comprising recycling the 100 Mo 2 C to form 100 MoO 3 .

11. A method of synthesizing 99m Tc pertechnetate in accordance with claim 10 , wherein the recycling comprises:
(i) washing the 100 Mo 2 C with 28% NH 3 (aq); and
(ii) applying the solution from (i) to synthesis of (NH 4 ) 6 Mo 7 O 24 .4H 2 O.

12. A method of synthesizing pertechnetate ( 99m TcO 4 − ) in accordance with claim 1 , further comprising:
prior to the bombarding, pressing the 100 Mo 2 C to form a compact powder; and
sintering the compact powder.

13. A method of synthesizing pertechnetate ( 99m TcO 4 − ) in accordance with claim 12 , wherein the sintering the compact powder comprises heating the compact powder under vacuum at about 600° C.

Assignees

• Univ Washington

Inventors

• Richards Vernal
• Lapi Suzanne

Classifications

• G21G2001/0042

  Technetium · CPC title

• G21G1/001 Primary

  Recovery of specific isotopes from irradiated targets · CPC title

• C01B31/34

  Chemistry & Metallurgy · mapped topic

• G21G2001/0036

  Molybdenum · CPC title

• A61K51/0489

  Phosphates or phosphonates, e.g. bone-seeking phosphonates; (phospholipids: A61K51/0408; nucleotides or nucleic acids: A61K51/0491) · CPC title