Magnetic resonance hyperpolarization and multiple irradiation probe head

Patent metadata

Field	Value
Publication number	US-9448290-B2
Application number	US-201214128312-A
Country	US
Kind code	B2
Filing date	Jun 27, 2012
Priority date	Jun 28, 2011
Publication date	Sep 20, 2016
Grant date	Sep 20, 2016

Abstract

A hyperpolarization and multiple irradiation probe head, suitable for use in connection with magnetic resonance techniques (DNP-NMR, photo-DNP-NMR, ENDOR-EPR, MRI, DNP-MRI), comprising a RF transducer for generating and detecting a RF signal, wherein said RF transducer has a conducting element ( 2 ) allowing, together with at least one fully or partially connected grid polarizer made of conducting grid elements ( 1 ) which are reciprocally spaced so as the grid is at least partially transparent to a given microwave beam ( 3 ), controlled RF current paths and a substantially uniform RF magnetic field inside the RF transducer, wherein the grid polarizer ( 1 ) and the conducting element ( 2 ) forming the RF transducer are shaped and oriented to conform to said microwave beam phase fronts, said grid polarizer and said conducting element surrounding a sample ( 8 ), which is apt to be irradiated also by said microwaves ( 3 ); the probe head being also suited for a simultaneous irradiation of the sample with THz, FIR, IR, visible, and UV electromagnetic radiation.

First claim

The invention claimed is:

1. A magnetic resonance hyperpolarization and multiple irradiation probe head, apt to accommodate a sample therein to have it irradiated by a predetermined microwave (MW) beam having a given phase front and wavelength in vacuum λ mw , the probe including a radiofrequency (RF) transducer for generating and detecting a RF signal, wherein said RF transducer comprises:
an electrically conducting element;
a grid polarizer embodied by at least one grid made of conducting grid elements which are spaced to each other so as the grid is at least partially transparent to said MW beam, said grid being at least partially electrically connected or RF coupled to the conducting element,

wherein the grid polarizer and the electrically conducting element of the RF transducer are shaped and oriented to conform to said MW beam phase front, said grid polarizer and said electrically conducting element being placed so as to define a space enclosed therebetween to receive said sample.

2. Probe head according to claim 1 , wherein said electrically conducting element is a planar conducting plate of arbitrary thickness, which has a reflecting surface for said MW beam, said reflecting surface facing said grid polarizer.

3. Probe head according to claim 2 , wherein the reflecting surface of the electrically conducting element of the RF transducer is a corrugated surface so as to act as polarization-sensitive element for the MW radiation.

4. Probe head according to claim 1 , wherein said grid elements comprise wires, strips, rods or bar-like elements, preferably having cross-section size smaller than λ mw , where λ mw is the MW wavelength in vacuum.

5. Probe head according to claim 4 , wherein said electrically conducting element is a planar conducting plate of arbitrary thickness, which has a reflecting surface for said MW beam, said reflecting surface facing said grid polarizer, and wherein said at least one grid polarizer is composed by parallel and mutually spaced wires or strips, arranged according to a predetermined direction on a planar surface, with mutual relative distance preferably smaller than λ mw /2, where λ mw is the MW wavelength in vacuum.

6. Probe head according to claim 5 , wherein said grid polarizer is arranged parallel to said electrically conducting element.

7. Probe head according to claim 6 , wherein each grid element and the conducting element are electrically connected to obtain a substantially U-shaped distributed coil RF transducer having two parallel sides, apt to surround a sample placed therein.

8. Probe head according to claim 1 , wherein one or more microfluidic channels are arranged to allow a fluid to be encased between said electrically conducting element and said grid polarizer and possibly to flow.

9. Probe head according to claim 1 , wherein said space enclosed within said RF transducer includes a dielectric region, possibly surrounding the grid elements, comprising an anti-reflection coating or a series of dielectric areas to minimize the reflection of the incoming MW radiation.

10. Probe head according to claim 1 , wherein selected series of electrically conducting grid elements are electrically connected or RF coupled to a single RF circuit or to independent RF circuits.

11. Probe head according to claim 1 , wherein the grid polarizer is made of a series of strip elements, each strip element facing the conducting element, the grid polarizer and the conducting element being coupled by means of RF electric and magnetic fields, said strip elements and said electrically conducting element acting as a microstrip-like RF transducer.

12. Probe head according to claim 11 , wherein each strip is segmented in several sequential pieces, each of them acting, together with the facing conducting element, as a microstrip-like RF transducer, said RF transducers being connected to different RF circuits of the probe head.

13. Probe head according to claim 1 , wherein the RF transducer is composed by two facing planar grid polarizers electrically connected or RF coupled to each other, with substantially parallel grid elements, one of them operating as electrically conducting element.

14. Probe head according to claim 13 , wherein said two facing grid polarizers composing the RF transducer are electrically connected to each other to achieve a single solenoid, wherein the grid elements composing the two grid polarizers are arranged substantially parallel to each other.

15. Probe head according to claim 13 , wherein one of said grid polarizers of the RF transducer is composed by adjacent conducting strips with mutual distance smaller than λ mw , in order to behave as a highly reflecting surface for the MW beam.

16. Probe head according to claim 13 , wherein one of said two facing grids composing the RF transducer is placed substantially parallel to a reflecting surface for the MW beam.

17. Probe head according to claim 1 , comprising a MW resonator.

18. Probe head according to claim 1 , comprising a further grid polarizer between the grid polarizer and the conducting element, said further grid polarizer being electrically connected or RF coupled to the grid polarizer and to the electrically conducting element.

19. Probe head according to claim 1 , wherein the shape of said grid elements is such that they act as a plate of a condenser, the other plate of said condenser being represented by a side of the conducting element, possibly including between said grid elements and said conducting element a dielectric region.

20. Use of a probe head as defined in claim 1 , wherein a sample placed therein is irradiated by MW and/or higher frequency electromagnetic waves, and the probe head acts as RF signal transducer.

21. Use of a probe head according to claim 20 , wherein said higher frequency electromagnetic waves belong to the ultraviolet region of the electromagnetic spectrum.

Assignees

• Annino Giuseppe
• Macor Alessandro
• De Rijk Emile
• Alberti Stefano
• Consiglio Nazionale Ricerche

Inventors

• Annino Giuseppe
• Macor Alessandro
• De Rijk Emile
• Alberti Stefano

Classifications

• G01R33/302

  Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips · CPC title

• G01R33/3456

  Stripline resonators · CPC title

• G01R33/282 Primary

  Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent · CPC title

• G01R33/20

  involving magnetic resonance (medical aspects A61B5/055; magnetic resonance gyrometers G01C19/60) · CPC title

• G01R33/62

  using double resonance (G01R33/24 takes precedence) · CPC title