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Cell analyzing apparatus and cell analyzing method
US9448228B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9448228-B2 |
| Application number | US-201313917534-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 13, 2013 |
| Priority date | Jun 15, 2012 |
| Publication date | Sep 20, 2016 |
| Grant date | Sep 20, 2016 |
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Abstract
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A cell analyzing apparatus includes: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis.
First claim
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What is claimed is: 1. A cell analyzing apparatus comprising: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis, wherein the frequency analysis is a Fast Fourier Transform applied to the data of the histogram relating to the fluorescence intensity and the number of nuclear stained cells, and wherein the analysis controller determines the existence/nonexistence of the cancer cells by comparing an area under a curve of a waveform which is obtained from the result of the frequency analysis, with a predetermined threshold. 2. A cell analyzing apparatus comprising: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis, wherein the frequency analysis is a Fast Fourier Transform applied to the data of the histogram relating to the fluorescence intensity and the number of nuclear stained cells, and wherein the analysis controller determines the existence/nonexistence of the cancer cells depending on whether or not a waveform which is obtained from the result of the frequency analysis ripples in a spatial frequency. 3. A cell analyzing apparatus comprising: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis, wherein the frequency analysis is a Fast Fourier Transform applied to the data of the histogram relating to the fluorescence intensity and the number of nuclear stained cells, and wherein the analysis controller determines the existence/nonexistence of the cancer cells depending on whether or not a waveform which is obtained from the result of the frequency analysis steeply attenuates in a direction toward a higher frequency in a low spatial frequency region. 4. A cell analyzing apparatus comprising: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis, wherein the frequency analysis is a Fast Fourier Transform applied to the data of the histogram relating to the fluorescence intensity and the number of nuclear stained cells, and wherein the analysis controller comprehensively determines a comparison between an area under a curve of a waveform which is obtained from the result of the frequency analysis, and a predetermined threshold, existence/nonexistence of a ripple in a spatial frequency, and existence/nonexistence of steep attenuation in a direction toward a higher frequency in a low spatial frequency region, thereby determining the existence/nonexistence of the cancer cells. 5. The cell analyzing apparatus according to claim 1 , wherein the predetermined threshold is a value of the area under the curve, which is obtained from normal cells of a living body. 6. A cell analyzing method comprising: using a histogram acquirer to perform measurement of a number of nuclear stained cells, and, by using a result of the measurement, acquiring a histogram indicating a fluorescence intensity; using an analysis controller to apply frequency analysis on data of the acquired histogram; and to determine existence/nonexistence of cancer cells based on a result of the frequency analysis, wherein the frequency analysis is a Fast Fourier Transform applied to the data of the histogram relating to the fluorescence intensity and the number of nuclear stained cells, and wherein the analysis controller determines the existence/nonexistence of the cancer cells by comparing an area under a curve of a waveform which is obtained from the result of the frequency analysis, with a predetermined threshold.
Assignees
Inventors
Classifications
- G06V20/69Primary
Microscopic objects, e.g. biological cells or cellular parts · CPC title
- G01N33/5091Primary
for testing the pathological state of an organism · CPC title
Frequency domain transformation; Autocorrelation · CPC title
Physics · mapped topic
Physics · mapped topic
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Frequently asked questions
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- What does patent US9448228B2 cover?
- A cell analyzing apparatus includes: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer,…
- Who is the assignee on this patent?
- Nihon Kohden Corp
- What technology area does this patent fall under?
- Primary CPC classification G06V20/69. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Sep 20 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).