5-substituted isoindoline compounds

Patent metadata

Field	Value
Publication number	US-9447070-B2
Application number	US-201414490554-A
Country	US
Kind code	B2
Filing date	Sep 18, 2014
Priority date	Aug 30, 2006
Publication date	Sep 20, 2016
Grant date	Sep 20, 2016

Abstract

This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

First claim

What is claimed is:

1. A compound of formula (I):

and pharmaceutically acceptable salts, solvates, and stereoisomers thereof, wherein:
X is CH 2 or C═O;
Z is: (CH 2 ) m , wherein m is 0 or 1; or NH;
R 1 is halogen or (C 1 -C 6 )alkyl, itself optionally substituted with one or more halogen; and
R 2 is hydrogen; halogen; or (C 1 -C 6 )alkyl, itself optionally substituted with one or more halogen.

2. The compound of claim 1 , wherein X is CH 2 .

3. The compound of claim 1 , wherein X is C═O.

4. The compound of claim 1 , wherein Z is (CH 2 ) m and m is 0.

5. The compound of claim 1 , wherein Z is (CH 2 ) m and m is 1.

6. The compound of claim 1 , wherein Z is NH.

7. The compound of claim 1 , wherein R 1 is chloro, methyl, or tert-butyl.

8. The compound of claim 1 , wherein R 2 is hydrogen; chloro or trifluoromethyl.

9. The compound of claim 1 , having the structure:

or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.

10. A pharmaceutical composition comprising a compound of claim 1 .

11. A single unit dosage form comprising a compound of claim 1 .

12. The single unit dosage form of claim 11 , which is suitable for oral or parenteral administration.

Assignees

• Celgene Corp

Inventors

• Muller George W
• Chen Roger Shen-Chu
• Ruchelman Alexander L

Classifications

• A61P7/00

  Drugs for disorders of the blood or the extracellular fluid · CPC title

• A61P37/02

  Immunomodulators · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P7/06

  Antianaemics · CPC title