Endoparasite control agent

Patent metadata

Field	Value
Publication number	US-9447042-B2
Application number	US-201214000974-A
Country	US
Kind code	B2
Filing date	Mar 1, 2012
Priority date	Mar 2, 2011
Publication date	Sep 20, 2016
Grant date	Sep 20, 2016

Abstract

Provided are an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I):

or

a salt thereof as an active ingredient, and a method for controlling endoparasites, comprising orally or parenterally administering the endoparasite control agent.

First claim

The invention claimed is:

1. A method for controlling endoparasites, wherein the endoparasite is selected from the subclass Rhabditia or Spiruria, in a mammal or bird, comprising orally or parenterally administering an effective amount of the endoparasite control agent comprising a carboxamide derivative represented by the general formula(I):

wherein A represents a (C 1 -C 2 ) alkylene group which is optionally substituted by a (C 1 -C 6 ) alkyl group and/or a (C 3 -C 6 ) cycloalkyl group
E represents a hydrogen atom,
each X may be the same or different, and represents a halogen atom; or a (C 1 -C 6 ) alkyl group optionally substituted by a halogen atom;
m represents an integer of 0, 1 or 2,
each Y may be the same or different, and represents a halogen atom; a (C 1 -C 6 ) alkyl group optionally substituted by a halogen atom;
n represents an integer of 0, 1, 2 or 3 and
Z represents CH; or CY (wherein Y is as defined above), or a salt thereof as an active ingredient to said mammal or a bird.

2. The method according to claim 1 , wherein an effective amount of the endoparasite control agent is administered to a mammal.

3. The method according to claim 2 , wherein the mammal is a domestic animal.

4. The method according to claim 2 , wherein the mammal is human.

5. The method according to claim 1 , wherein
m represents 1 or 2.

6. The method according to claim 1 , wherein
m represents 1,
each Y may be the same or different, and represents a halogen atom or a (C 1 -C 6 )alkyl group optionally substituted by a halogen atom, and
n represents an integer of 1 to 3.

7. The method according to claim 1 , wherein the carboxamide derivative represented by the general formula (I) is a compound of the formula:

8. The method according to claim 1 , wherein the endoparasite is Haemonchus contortus.

Assignees

• Kita Kiyoshi
• Suwa Akiyuki
• Univ Tokyo
• Nihon Nohyaku Co Ltd

Inventors

• Kita Kiyoshi
• Suwa Akiyuki

Classifications

• A61P33/10

  Anthelmintics · CPC title

• A61P33/02

  Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis · CPC title

• A61P33/06

  Antimalarials · CPC title

• A61P33/04

  Amoebicides · CPC title

• A61P33/00

  Antiparasitic agents · CPC title